Evidence map›Paper›PMID 36001977›Full record

ArticleCell reports2022

Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain.

Megan M McCollum, Megan Larmore, Shingo Ishihara, Leo C T Ng, Louise F Kimura, Eduardo Guadarrama, My C Ta, Thuy N Vien, Grant B Frost, Karl A Scheidt and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. [Research progress on the causes of pain in knee osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Pooled it
  2. Article
  3. Molecular docking andJournal of Taibah University Medical Sciences · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Megan M McCollumDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Megan LarmoreDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Shingo IshiharaDivision of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA.
Leo C T NgDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Louise F KimuraDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Eduardo GuadarramaDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
My C TaDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Thuy N VienDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Grant B FrostDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Karl A ScheidtDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Rachel E MillerDivision of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA.
Paul G DeCaenDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: paul.decaen@northwestern.edu.
Northwestern University · USRush University Medical Center · US

Funding

Neurobiology Core CP30AR079206 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Anne-Marie Malfait · 2021 to 2026
$4.7M
Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
The Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and PainR01AR077019 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Rachel Elizabeth Miller · 2021 to 2026
$2.7M
Molecular dysregulation of primary cilia TRPP2 channels caused by Finger 1 variantsR01DK123463 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DECAEN, PAUL GREGORY · 2019 to 2023
$2.0M
Cilia calcium dysregulation in polycystic kidney diseaseR01DK131118 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Paul Gregory DeCaen · 2022 to 2026
$1.9M
NIAMS NIH HHS P30 AR079206NIAMS NIH HHS R01 AR077019NIDDK NIH HHS R01 DK123463NIDDK NIH HHS R01 DK131118NIGMS NIH HHS T32 GM008382
6 · The paper itself

Abstract

Voltage-gated sodium channels (Na

Indexed as

TamoxifenVoltage-Gated Sodium ChannelsAction PotentialsGanglia, SpinalHumansNociceptorsPainTamoxifenVoltage-Gated Sodium ChannelsCP: NeuroscienceDRG neuronsmolecular pharmacologynociceptorsosteoarthritispainsodium channel

Identifiers

PMID36001977
PMCPMC9523973
OpenAlexW4292755761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.