Evidence map›Paper›PMID 36001965›Full record

ArticleCell reports2022

Heterotropic roles of divalent cations in the establishment of allostery and affinity maturation of integrin αXβ2.

Pragya Manandhar, Zahra Mazhar, Omar Abousaway, Collins Aboagye, Zeinab Moussa, Daniel Lim, Tannon Yu, James Byrnes, James M Briggs, Mehmet Sen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Expression and Characterization of Intein-Cyclized Trimer ofInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Pragya ManandharDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Zahra MazharDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Omar AbousawayDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Collins AboagyeDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Zeinab MoussaDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Daniel LimDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Tannon YuDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
James ByrnesNational Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973, USA.
James M BriggsDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.
Mehmet SenDepartment of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. Electronic address: msen2@cougarnet.uh.edu.
University of Houston · USBrookhaven National Laboratory · US

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
A Simultaneous SAXS/WAXS Detector System for Solving Biological StructuresS10OD012331 · OD · STATE UNIVERSITY NEW YORK STONY BROOK · PI ALLAIRE, MARC · 2012 to 2012
$1.1M
The atomic basis of leukocyte adhesion receptor (CD11c/CD18) activation and antagonism in solutionR03AI139651 · NIAID · UNIVERSITY OF HOUSTON · PI SEN, MEHMET · 2018 to 2019
$153k
NIAID NIH HHS R03 AI139651NIGMS NIH HHS P30 GM133893NIH HHS S10 OD012331
6 · The paper itself

Abstract

Allosteric activation and silencing of leukocyte β2-integrins transpire through cation-dependent structural changes, which mediate integrin biosynthesis and recycling, and are essential to designing leukocyte-specific drugs. Stepwise addition of Mg

Indexed as

Integrin alphaXbeta2Cations, DivalentLigandsProtein BindingProtein Structure, TertiaryCations, DivalentIntegrin alphaXbeta2Ligandsaffinity maturationallosteryCD11cCD18CP: Molecular biologyintegrinαX I-domain

Identifiers

PMID36001965
PMCPMC9440770
OpenAlexW4292756170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.