Evidence map›Paper›PMID 36001861›Full record

ArticleJCO precision oncology2022

Refining Prognosis in Localized Gastrointestinal Stromal Tumor: Clinical Significance of Phosphatase and Tensin Homolog Low Expression and Gene Loss.

Xiaolan Feng, Haocheng Li, Joanna Fourquet, Mehdi Brahmi, Armelle Dufresne, Alexandra Meurgey, Isabelle Ray-Coquard, Qing Wang, Julien Bollard, Francoise Ducimetiere and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in JCO precision oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Xiaolan FengDepartment of Medicine Oncology, Tom Baker Cancer Center, Calgary, Alberta, Canada.ORCID 0000-0002-7333-8198
Haocheng LiDepartment of Mathematics and Statistics, University of Calgary, Calgary, Alberta, Canada.
Joanna FourquetOncoSarc, INSERM U1037, Cancer Research Center in Toulouse, Toulouse, France.
Mehdi BrahmiDepartment of Medical Oncology, Centre Léon Bérard, Lyon, France.ORCID 0000-0001-9904-166X
Armelle DufresneDepartment of Medical Oncology, Centre Léon Bérard, Lyon, France.
Alexandra MeurgeyDepartment of Pathology, Institut Claudius Régaud, IUCT-Oncopole, Toulouse, France.
Isabelle Ray-CoquardDepartment of Medical Oncology, Centre Léon Bérard, Lyon, France.ORCID 0000-0003-2472-8306
Qing WangDepartment of Biopathology, Centre Léon Bérard, Lyon, France.ORCID 0000-0001-6575-9892
Julien BollardDepartment of Medical Oncology, Centre Léon Bérard, Lyon, France.ORCID 0000-0002-9378-5665
Francoise DucimetiereDepartment of Medical Oncology, Centre Léon Bérard, Lyon, France.ORCID 0000-0003-2889-685X
Frederic ChibonOncoSarc, INSERM U1037, Cancer Research Center in Toulouse, Toulouse, France.
Jean-Yves BlayDepartment of Medical Oncology, Centre Léon Bérard, Lyon, France.ORCID 0000-0001-7190-120X
Centre Léon Bérard · FRInserm · FRInstitut Claudius Regaud · FRUniversité Claude Bernard Lyon 1 · FRUniversity of British Columbia · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the use of PTEN biomarker to improve prognostic stratification in patients with localized gastrointestinal stromal tumor (GIST).

methodsPTEN expression and genomic analysis were performed on two independent GIST-60 (n = 60) and GIST-100 (n = 100) cohorts, respectively.

resultsPTEN expression was significantly lower in patients with local and metastatic recurrent tumor compared with those with no recurrence (

conclusionPTEN low expression/gene loss is an independent significant prognostic factor and a promising component to strengthen the clinical prognostic tools in patients with localized GIST.

Indexed as

Gastrointestinal NeoplasmsGastrointestinal Stromal TumorsDisease-Free SurvivalHumansPrognosisTensinsTensins

Identifiers

PMID36001861
PMCPMC9489173
OpenAlexW4292995296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.