Evidence map›Paper›PMID 36001652›Full record

ArticleScience advances2022

Transcription factor-nucleosome dynamics from plasma cfDNA identifies ER-driven states in breast cancer.

Satyanarayan Rao, Amy L Han, Alexis Zukowski, Etana Kopin, Carol A Sartorius, Peter Kabos, Srinivas Ramachandran

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Cancer-Like Fragmentomic Characteristics of Somatic Variants in Cell-Free DNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Cell-Free DNA-Based Methods to Map Chromatin.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Satyanarayan RaoDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0001-7678-3505
Amy L HanDepartment of Medicine/Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-1890-3510
Alexis ZukowskiDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-1212-2254
Etana KopinDepartment of Medicine/Division of Medical Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
Carol A SartoriusDepartment of Pathology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-9170-3988
Peter KabosRNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-1500-471X
Srinivas RamachandranDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-2929-1377
The Medical Center of Aurora · USUniversity of Colorado Denver · USUniversity of Colorado Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Tissue Bank and Biomarkers CoreP50CA058187 · NCI · UNIVERSITY OF COLORADO DENVER · PI MILLER, YORK E · 1992 to 2018
$43.8M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
Hormones and Tumor Initiating Cells in Human Breast CancersR01CA140985 · NCI · UNIVERSITY OF COLORADO DENVER · PI SARTORIUS, CAROL ANN · 2011 to 2020
$3.0M
Cancer-associated fibroblasts in estrogen receptor positive breast cancer.R01CA205044 · NCI · UNIVERSITY OF COLORADO DENVER · PI KABOS, PETER · 2016 to 2020
$1.8M
NCI NIH HHS P30 CA046934NCI NIH HHS P50 CA058187NCI NIH HHS R01 CA140985NCI NIH HHS R01 CA205044NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Genome-wide binding profiles of estrogen receptor (ER) and FOXA1 reflect cancer state in ER

Indexed as

Breast NeoplasmsCell-Free Nucleic AcidsFemaleGene Expression RegulationGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-alphaHumansNucleosomesReceptors, EstrogenCell-Free Nucleic AcidsHepatocyte Nuclear Factor 3-alphaNucleosomesReceptors, Estrogen

Identifiers

PMID36001652
PMCPMC9401618
OpenAlexW4293101932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.