Evidence map›Paper›PMID 36001481›Full record

ArticleJournal of chemical information and modeling2022

Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation.

Iris N Smith, Jennifer E Dawson, James Krieger, Stetson Thacker, Ivet Bahar, Charis Eng

Open access · greenAbstract read
In one paragraph

Article in Journal of chemical information and modeling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. PTEN: a new dawn in Parkinson's disease treatment.Frontiers in cellular neuroscience · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. The orchestrated signaling by PI3Kα and PTEN at the membrane interface.Computational and structural biotechnology journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Iris N SmithGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, United States.
Jennifer E DawsonGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, United States.
James KriegerDepartment of Computational and Systems Biology, University of Pittsburgh, 800 Murdoch Building, 3420 Forbes Avenue, Pittsburgh, Pennsylvania 15260, United States.
Stetson ThackerGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, United States.
Ivet BaharDepartment of Computational and Systems Biology, University of Pittsburgh, 800 Murdoch Building, 3420 Forbes Avenue, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0001-9959-4176
Charis EngGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, United States.ORCID 0000-0002-3693-5145
Cleveland Clinic Lerner College of Medicine · USUniversity of Pittsburgh · USCleveland Clinic · US

Funding

TrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MURPHY, ROBERT F · 2012 to 2021
$16.3M
RESEARCH ONCOLOGY TRAINING GRANTT32CA059366 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JACKSON, MARK W. · 1993 to 2025
$5.5M
Toward a Deeper Understanding of Allostery and Allotargeting by Computational ApproachesR01GM139297 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ivet Bahar · 2021 to 2026
$2.8M
Unraveling the PTEN Interactome: Modeling Structural and Functional Dynamic Network Architecture for Therapeutic Modulation in Cancer and AutismK99GM143552 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, IRIS NIRA · 2021 to 2022
$200k
NCI NIH HHS T32 CA059366NIGMS NIH HHS K99 GM143552NIGMS NIH HHS P41 GM103712NIGMS NIH HHS R01 GM139297
6 · The paper itself

Abstract

The phosphatase and tensin homologue deleted on chromosome 10 (

Indexed as

Phosphatidylinositol 3-KinasesPTEN PhosphohydrolaseMolecular Dynamics SimulationPhosphorylationProtein Structure, SecondarySignal TransductionPhosphatidylinositol 3-KinasesPTEN Phosphohydrolase

Identifiers

PMID36001481
PMCPMC9472802
OpenAlexW4293275348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.