Evidence map›Paper›PMID 36001434›Full record

ArticleAddiction biology2022

Peer-induced cocaine seeking in rats: Comparison to nonsocial stimuli and role of paraventricular hypothalamic oxytocin neurons.

Lindsey R Hammerslag, Bree A Humburg, Samantha G Malone, Joshua S Beckmann, Kathryn E Saatman, Valery Grinevich, Michael T Bardo

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lindsey R HammerslagDepartment of Psychology, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0003-0750-6656
Bree A HumburgDepartment of Psychology, University of Kentucky, Lexington, Kentucky, USA.
Samantha G MaloneDepartment of Psychology, University of Kentucky, Lexington, Kentucky, USA.
Joshua S BeckmannDepartment of Psychology, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-0598-2926
Kathryn E SaatmanDepartment of Physiology, and Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, Kentucky, USA.
Valery GrinevichDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Michael T BardoDepartment of Psychology, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-8632-3032
University of Kentucky · USHeidelberg University · DE

Funding

Training in Drug Abuse Related Research.T32DA016176 · NIDA · UNIVERSITY OF KENTUCKY · PI DWOSKIN, LINDA P · 2004 to 2020
$4.0M
Social Cues and Drug RelapseR21DA041755 · NIDA · UNIVERSITY OF KENTUCKY · PI BARDO, MICHAEL T · 2017 to 2018
$398k
Calcium Imaging of Central Amygdala Activity after Fentanyl EscalationF31DA057050 · NIDA · UNIVERSITY OF KENTUCKY · PI MALONE, SAMANTHA · 2022 to 2023
$78k
NIDA NIH HHS F31 DA057050NIDA NIH HHS R21 DA041755NIDA NIH HHS T32 DA016176
6 · The paper itself

Abstract

The purpose of this study was to determine if social vs nonsocial cues (peer vs light/tone) can serve as discriminative stimuli to reinstate cocaine seeking. In addition, to assess a potential mechanism, an oxytocin (OT) promoter-linked hM3Dq DREADD was infused into the paraventricular nucleus of the hypothalamus to determine whether peer-induced cocaine seeking is decreased by activation of OT neurons. Male rats underwent twice-daily self-administration sessions, once with cocaine in the presence of one peer (S+) and once with saline in the presence of a different peer (S-). Another experiment used similar procedures, except the discriminative stimuli were nonsocial (constant vs flashing light/tone), with one stimulus paired with cocaine (S+) and the other paired with saline (S-). A third experiment injected male and female rats with OTp-hM3Dq DREADD or control virus into PVN and tested them for peer-induced reinstatement of cocaine seeking following clozapine (0.1 mg/kg). Although acquisition of cocaine self-administration was similar in rats trained with either peer or light/tone discriminative stimuli, the latency to first response was reduced by the peer S+, but not by the light/tone S+. In addition, the effect of the conditioned stimulus was overshadowed by the peer S+ but not by the light/tone S+. Clozapine blocked the effect of the peer S+ in rats receiving the OTp-hM3Dq DREADD virus, but not in rats receiving the control virus. These results demonstrate that a social peer can serve as potent trigger for drug seeking and that OT in PVN modulates peer-induced reinstatement of cocaine seeking.

Indexed as

ClozapineCocaineCocaine-Related DisordersAnimalsCuesExtinction, PsychologicalFemaleMaleNeuronsOxytocinParaventricular Hypothalamic NucleusRatsSelf AdministrationClozapineCocaineOxytocincocaineoxytocinself-administrationsocial peer

Identifiers

PMID36001434
PMCPMC9413367
OpenAlexW4292454318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.