ArticleLasers in medical science2022
Utilization of gold nanoparticles for the detection of squamous cell carcinoma of the tongue based on laser-induced fluorescence and diffuse reflectance characteristics: an in vitro study.
Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Doxorubicin-loaded gold nanoparticles for enhanced anticancer efficacy: in vitro, in vivo, and FTIR-based tissue analysis.Scientific reports · 2026Article
- DoE-Optimized Chitosan-Coated pH-Sensitive Liposomes for Targeted Nose-to-Brain Delivery of Temozolomide.AAPS PharmSciTech · 2026Article
- Metabolomic profiling and biological evaluation demonstrate the antioxidant, PPAR-γ, TAAR1, and FABP4 modulatory potential of Strelitzia species.Scientific reports · 2026Article
- Curcumin-Loaded Nanomaterials as Carriers for Photodynamic Therapy Against Cancers.Gels (Basel, Switzerland) · 2025Review
- Utilizing Laser-Induced Fluorescence to Evaluate the Efficiency of Carbon Dioxide and Diode Lasers in Dentin Sealing after Tooth Preparation: An in-vitro Study.Journal of fluorescence · 2025Article
- A Review on Biomedical Applications of Plant Extract-Mediated Metallic Ag, Au, and ZnO Nanoparticles and Future Prospects for Their Combination with Graphitic Carbon Nitride.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Selective and naked eye colorimetric detection of creatinine through aptamer-based target-induced passivation of gold nanoparticles.RSC advances · 2024Article
- Label-Free Optical Spectroscopy for Early Detection of Oral Cancer.Diagnostics (Basel, Switzerland) · 2022Review
- Optical Characterization of Biological Tissues Based on Fluorescence, Absorption, and Scattering Properties.Diagnostics (Basel, Switzerland) · 2022Article
- Gold nanoparticles loaded chitosan encapsulate 6-mercaptopurine as a novel nanocomposite for chemo-photothermal therapy on breast cancer.BMC chemistry · 2022Article
- Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer model.BMC chemistry · 2022Article
- Nanotechnology applications in oral pathology: A scoping review.Journal of oral and maxillofacial pathology : JOMFPReview
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squamous cell carcinoma is a very common type of oral cancer that affects the health of people with an unacceptably high mortality rate attributed to the difficulties in detecting the disease at an early stage. Therefore, effective techniques for early diagnosis and effective therapy of oral cancer are necessary. In the present study, we exploit the ability of gold nanoparticles (AuNPs) to undergo coupled surface plasmon resonance when closely spaced to improve diagnosing squamous cell carcinoma of the tongue. The prepared AuNPs are characterized by UV-VIS spectroscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and transmission electron microscopy. The size of the prepared AuNPs is 12 ± 2 nm with narrow size distributions and exhibited high stability with a zeta potential of - 16.5 mV. The light fluorescence of the normal and cancer cells is recorded before and after NP addition using a spectrometer upon excitation by 405-nm laser irradiation. Furthermore, the light reflectance of the examined samples is measured at different laser wavelengths (red to NIR region). The obtained results show that the cancer cells mixed with AuNPs produce a higher fluorescence peak at 489.2 nm than the cancer cells without AuNPs. Moreover, the optical diffuse reflectance analyses reveal that the addition of AuNPs enhances cancer detection especially at the 635-nm irradiation with sensitivity (94%), specificity (87%), and overall accuracy (91%).
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