Evidence map›Paper›PMID 36001151›Full record

ArticleJournal of bone and mineral metabolism2022

Risk factors for subchondral insufficiency fracture of the femoral head in renal transplant patients.

Yoshitoshi Higuchi, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Taiki Kusano, Hideyoshi Sawada, Kazuyoshi Kobayashi, Shunji Narumi, Yoshihiko Watarai, Norihiko Goto and 2 more

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In one paragraph

Article in Journal of bone and mineral metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yoshitoshi HiguchiDepartment.of Orthopaedic.Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya city, 466-8650, Japan. rdggd215@yahoo.co.jp.ORCID http://orcid.org/0000-0002-1112-2682
Toshihide TomosugiDepartment.of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya city, Japan.
Kenta FutamuraDepartment.of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya city, Japan.
Manabu OkadaDepartment.of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya city, Japan.
Taiki KusanoDepartment.of Orthopaedic.Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya city, 466-8650, Japan.
Hideyoshi SawadaDepartment.of Orthopaedic.Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya city, 466-8650, Japan.
Kazuyoshi KobayashiDepartment.of Orthopaedic.Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya city, 466-8650, Japan.
Shunji NarumiDepartment.of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya city, Japan.
Yoshihiko WataraiDepartment.of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya city, Japan.
Norihiko GotoDepartment.of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya city, Japan.
Toshihiro AndoDepartment.of Orthopaedic.Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya city, 466-8650, Japan.
Koji SatoDepartment.of Orthopaedic.Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya city, 466-8650, Japan.
Japanese Red Cross Nagoya Daini Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRisk factors associated with subchondral insufficiency fracture (SIF) of the femoral head have not been established. The aim of the present study was to determine the incidence and risk factors for SIF of the femoral head following renal transplantation (RT). MATERIALS AND

methodsWe analyzed the cases of 681 RT patients (mean age at surgery: 49.5 ± 13.6 years, 249 women, 432 men) to determine the incidence of SIF. Hip magnetic resonance imaging (MRI) was performed 6 months post-RT. The following potential predictors of SIF were evaluated: (1) patient's condition at RT: bone mineral density (BMD), pre-RT laboratory values including calcium (Ca), phosphorus (P), calcium-phosphorus product (Ca × P), and intact parathyroid hormone; the patient and donor's blood relationship; and mismatching number of human leukocyte antigens (HLAs), and (2) post-RT dosage(s) of steroid(s), the immunosuppressive regimen, and the incidence of acute rejection.

resultsSIF was observed in 15 hips (13 patients, 1.9%). We successfully matched 39 patients without SIF. A multivariate logistic regression analysis adjusted for cumulative dosages of steroids, revealed the following were risk factors for SIF: osteoporosis (OR: 11.4, p = 0.046), lumbar BMD (OR: 0.003, p = 0.038), pre-RT serum P (OR 2.68, p = 0.004), and pre-RT serum Ca × P (OR: 1.11, p = 0.005).

conclusionSince osteoporosis, the lumbar BMD, serum P, and serum Ca × P were identified as risk factors for a post-RT SIF, these factors should be evaluated before RT for the prediction of the SIF risk.

Indexed as

Fractures, StressKidney TransplantationOsteoporosisAdultBone DensityCalciumFemaleFemur HeadHumansMaleMiddle AgedPhosphorusRisk FactorsCalciumPhosphorusFemoral headMRIRenal transplantRisk factorSubchondral insufficiency fracture

Identifiers

PMID36001151
OpenAlexW4292883290

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.