Evidence map›Paper›PMID 36001145›Full record

ArticleClinical oral investigations2022

Antiresorptive therapy and dental implant survival: an up to 20-year retrospective cohort study in women.

Yu-Chi Cheng, Rolf Ewers, Katherine Morgan, Muneki Hirayama, Laura Murcko, John Morgan, Edmara T P Bergamo, Estevam A Bonfante

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In one paragraph

Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Long-term and sequential treatment for osteoporosis.Nature reviews. Endocrinology · 2023
    Review
  10. Article
  11. Article
  12. An engineering perspective of ceramics applied in dental reconstructions.Journal of applied oral science : revista FOB · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yu-Chi ChengDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Rolf EwersUniversity Hospital for Cranio-Maxillofacial and Oral Surgery and CMF Institute Vienna, Vienna, Austria.
Katherine MorganImplant Dentistry Centre, Boston, MA, USA.
Muneki HirayamaImplant Dentistry Centre, Boston, MA, USA.
Laura MurckoImplant Dentistry Centre, Boston, MA, USA.
John MorganImplant Dentistry Centre, Boston, MA, USA.
Edmara T P BergamoDepartment of Prosthodontics and Periodontology, University of Sao Paulo - Bauru School of Dentistry, 9-75 Octavio Pinheiro Brizola, Bauru, SP, 17012-901, Brazil. edmaratatiely@gmail.com.
Estevam A BonfanteDepartment of Prosthodontics and Periodontology, University of Sao Paulo - Bauru School of Dentistry, 9-75 Octavio Pinheiro Brizola, Bauru, SP, 17012-901, Brazil.
Implant Sciences (United States) · USUniversidade de São Paulo · BRMassachusetts Institute of Technology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effects of antiresorptive treatment on the survival of plateau-root form dental implants. MATERIALS AND

methodsPatients undergoing antiresorptive therapy via oral or intravenous administration as well as patients not undergoing antiresorptive therapy and healthy control patients were included in this retrospective cohort study. In total, 1472 implants placed in 631 postmenopausal patients (M: 66.42 ± 9.10 years old), who were followed for a period of up to 20 years (8.78 ± 5.68 years). Kaplan-Meier survival analysis was performed, and univariate and multivariate Cox regression, clustered by each patient, was used to evaluate and study factors affecting the survival of their implants.

resultsImplants placed in patients undergoing oral antiresorptive treatment presented significantly higher survival rates, than implants placed in the osteoporosis/osteopenia control cohort (p value < 0.001), and similar survival rates, when compared to healthy controls (p value = 0.03). Additionally, clustered univariate and multivariate Cox regression analysis also revealed higher implant survival when oral antiresorptive drugs (p value = 0.01 and 0.007, respectively) were used, and lower implant survival in the presence of untreated osteoporosis/osteopenia (p value = 0.002 and 0.005, respectively). Overall, the 20-year implant survival in osteoporotic patients undergoing antiresorptive therapy was 94%. For the failed implants, newly replaced implants in patients under antiresorptive treatment presented a 10-year survival of 89%.

conclusionsLong-term plateau-root form implant survival in osteoporotic patients taking oral antiresorptives was similar to a healthy population and significantly higher than the untreated controls. CLINICAL RELEVANCE: These results suggest that plateau-root form implants provide a robust solution for treating tooth loss in patients, who are undergoing antiresorptive therapy.

Indexed as

Dental ImplantsOsteoporosisAgedCohort StudiesDental Implantation, EndosseousDental Restoration FailureFemaleFollow-Up StudiesHumansMiddle AgedRetrospective StudiesDental ImplantsAntiresorptivesClinical trialsDental biologyImplantsOsteoporosis

Identifiers

PMID36001145
OpenAlexW4293171387

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.