ArticleCerebral cortex (New York, N.Y. : 1991)2023
Doctor trustworthiness influences pain and its neural correlates in virtual medical interactions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Patient-Controlled Sedation in Port Implantation (PACSPI 2)-A Randomised Clinical Trial.Acta anaesthesiologica Scandinavica · 2026Trial
- The Role of Satisfaction, Trust, and Shared Decision-Making in Opioid Misuse Risk After Unmet Analgesic Preferences for Acute Pain.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Acceptance of pain neuroscience education in chronic musculoskeletal pain conditions: qualitative systematic review.Pain reports · 2026Review
- Shared-decision-making, trust in the healthcare system and health literacy are associated with self-reported pain levels: a population-based cross-sectional study in individuals living with a chronic health condition in Wales.BMC health services research · 2025Article
- The High-Risk Model of Threat Perception Modulates Learning of Placebo and Nocebo Effects and Functional Somatic Disorders.Brain sciences · 2025Review
- A cross-sectional study examining the role of doctors' trust in patients' requests for antibiotics: a neglected perspective.Archives of public health = Archives belges de sante publique · 2025Article
- Updating beliefs about pain following advice: Trustworthiness of social advice predicts pain expectations and experience.Cognition · 2024Article
- Addressing chronic pain disparities between Black and White people: a narrative review of socio-ecological determinants.Pain management · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Trust is an important component of the doctor-patient relationship and is associated with improved patient satisfaction and health outcomes. Previously, we reported that patient feelings of trust and similarity toward their clinician predicted reductions in evoked pain in response to painful heat stimulations. In the present study, we investigated the brain mechanisms underlying this effect. We used face stimuli previously developed using a data-driven computational modeling approach that differ in perceived trustworthiness and superimposed them on bodies dressed in doctors' attire. During functional magnetic resonance imaging, participants (n = 42) underwent a series of virtual medical interactions with these doctors during which they received painful heat stimulation as an analogue of a painful diagnostic procedure. Participants reported increased pain when receiving painful heat stimulations from low-trust doctors, which was accompanied by increased activity in pain-related brain regions and a multivariate pain-predictive neuromarker. Findings suggest that patient trust in their doctor may have tangible impacts on pain and point to a potential brain basis for trust-related reductions in pain through the modulation of brain circuitry associated with the sensory-discriminative and affective-motivational dimensions of pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.