Evidence map›Paper›PMID 36000926›Full record

ArticleCancer science2023

Induction of potent antitumor immunity by intradermal DNA injection using a novel needle-free pyro-drive jet injector.

Shinya Inoue, Izuru Mizoguchi, Jukito Sonoda, Eri Sakamoto, Yasuhiro Katahira, Hideaki Hasegawa, Aruma Watanabe, Yuma Furusaka, Mingli Xu, Toshihiko Yoneto and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. State-of-the-Art Cancer Immunotherapies.International journal of molecular sciences · 2024
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Shinya InoueDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Izuru MizoguchiDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Jukito SonodaDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Eri SakamotoDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Yasuhiro KatahiraDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Hideaki HasegawaDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Aruma WatanabeDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Yuma FurusakaDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Mingli XuDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Toshihiko YonetoDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.
Naoki SakaguchiDepartment of Device Application for Molecular Therapeutics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kazuhiro TeraiDepartment of Device Application for Molecular Therapeutics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kunihiko YamashitaDepartment of Device Application for Molecular Therapeutics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Takayuki YoshimotoDepartment of Immunoregulation, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2847-0341
Tokyo Medical University · JPThe University of Osaka · JP

Funding

Daicel CorporationMinistry of Education, Culture, Sports, Science and Technology, Japan
6 · The paper itself

Abstract

The current success of mRNA vaccines against COVID-19 has highlighted the effectiveness of mRNA and DNA vaccinations. Recently, we demonstrated that a novel needle-free pyro-drive jet injector (PJI) effectively delivers plasmid DNA into the skin, resulting in protein expression higher than that achieved with a needle syringe. Here, we used ovalbumin (OVA) as a model antigen to investigate the potential of the PJI for vaccination against cancers. Intradermal injection of OVA-expression plasmid DNA into mice using the PJI, but not a needle syringe, rapidly and greatly augmented OVA-specific CD8

Indexed as

COVID-19Vaccines, DNAAnimalsCD8-Positive T-LymphocytesCOVID-19 VaccinesDNAHumansImmunoglobulin GInjections, IntradermalMiceMice, Inbred C57BLOvalbuminCOVID-19 VaccinesDNAImmunoglobulin GOvalbuminVaccines, DNAantitumor immunityDNA vaccinegeneration of CTLsintradermal injectionpyro-drive jet injector

Identifiers

PMID36000926
PMCPMC9807518
OpenAlexW4293211442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.