ArticlePlant physiology2022
ECERIFERUM1-6A is required for the synthesis of cuticular wax alkanes and promotes drought tolerance in wheat.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 71 citations in OpenAlex.
- Cuticular Waxes in Altered Environments and Their Role in Leaf Water Loss Dynamics.Plant, cell & environment · 2026Review
- The PtrC2H2.2-6-PtrCYP86A7/A8 Module Regulates Poplar Drought Tolerance Through Mediating Cutin and Wax Biosynthesis Pathways.Plant biotechnology journal · 2026Article
- Comparative Metabolomics Reveals Family-Genus-Specific Chemical Signatures and Potential Recognition Mechanisms inMolecules (Basel, Switzerland) · 2026Article
- From glossy to glaucous: How TaMYB96-2D controls wax deposition and drought resilience.Plant physiology · 2026Article
- Integrative Transcriptomics Reveals Regulatory Networks Underlying Fatty Acid and Lacquer Wax Formation in Fruit ofPlants (Basel, Switzerland) · 2026Article
- Structural basis of VLCFA chain-length determination by the KCS6-CER2 complex in plants.Science advances · 2025Article
- Characterization of volatiles in tea leaf cuticular wax during white tea processing across distinct climatic regions.Food chemistry: X · 2025Article
- Integrated lipidomics and physiological analyses reveal the critical role of leaf sheath wax remodeling in wheat (Triticum aestivum L.) drought resistance.BMC plant biology · 2025Article
- Biochemical Insights into Lipid Remodeling in Wheat Anthers Under High-Temperature Stress.International journal of molecular sciences · 2025Article
- Exploring Molecular Mechanisms in Wheat against Drought Stress from Sustainable Resilience Strategies To Emerging Innovative Approaches.Current microbiology · 2025Review
- Climatic stress-induced changes in plant chemistry alter the compound-specific degradation of litter during decomposition.The New phytologist · 2025Article
- Integrative omics of the genetic basis for wheat WUE and drought resilience reveal the function of TaMYB7-A1.Nature communications · 2025Article
- Enhancing drought resilience in crops: mechanistic approaches in the face of climate challenge.Plant molecular biology · 2025Review
- Research on the regulation mechanism of drought tolerance in wheat.Plant cell reports · 2025Review
- Exploring Drought Resistance Genes from the Roots of the Wheat Cultivar Yunhan1818.International journal of molecular sciences · 2024Article
- Arabidopsis DREB26/ERF12 and its close relatives regulate cuticular wax biosynthesis under drought stress condition.The Plant journal : for cell and molecular biology · 2024Article
- Impact of Mild Field Drought on the Aroma Profile and Metabolic Pathways of Fresh Tea (Foods (Basel, Switzerland) · 2024Article
- Wheat Transcription Factor TaMYB60 Modulates Cuticular Wax Biosynthesis by ActivatingInternational journal of molecular sciences · 2024Article
- Comparative physiological and transcriptomic analyses reveal genotype specific response to drought stress in Siberian wildrye (Elymus sibiricus).Scientific reports · 2024Article
- Gas Chromatography-Mass Spectrometry Metabolite Analysis Combined with Transcriptomics Reveals Genes Involved in Wax Biosynthesis inInternational journal of molecular sciences · 2024Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
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Abstract
Cuticular waxes cover the aerial surfaces of land plants and protect them from various environmental stresses. Alkanes are major wax components and contribute to plant drought tolerance, but the biosynthesis and regulation of alkanes remain largely unknown in wheat (Triticum aestivum L.). Here, we identified and functionally characterized a key alkane biosynthesis gene ECERIFERUM1-6A (TaCER1-6A) from wheat. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9)-mediated knockout mutation in TaCER1-6A greatly reduced the contents of C27, C29, C31, and C33 alkanes in wheat leaves, while TaCER1-6A overexpression significantly increased the contents of these alkanes in wheat leaves, suggesting that TaCER1-6A is specifically involved in the biosynthesis of C27, C29, C31, and C33 alkanes on wheat leaf surfaces. TaCER1-6A knockout lines exhibited increased cuticle permeability and reduced drought tolerance, whereas TaCER1-6A overexpression lines displayed reduced cuticle permeability and enhanced drought tolerance. TaCER1-6A was highly expressed in flag leaf blades and seedling leaf blades and could respond to abiotic stresses and abscisic acid. TaCER1-6A was located in the endoplasmic reticulum, which is the subcellular compartment responsible for wax biosynthesis. A total of three haplotypes (HapI/II/III) of TaCER1-6A were identified in 43 wheat accessions, and HapI was the dominant haplotype (95%) in these wheat varieties. Additionally, we identified two R2R3-MYB transcription factors TaMYB96-2D and TaMYB96-5D that bound directly to the conserved motif CAACCA in promoters of the cuticular wax biosynthesis genes TaCER1-6A, TaCER1-1A, and fatty acyl-CoA reductase4. Collectively, these results suggest that TaCER1-6A is required for C27, C29, C31, and C33 alkanes biosynthesis and improves drought tolerance in wheat.
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