Evidence map›Paper›PMID 36000876›Full record

ArticleInfection and immunity2022

Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments.

Amber M Frye, Monir Ejemel, Lisa Cavacini, Yang Wang, Michael J Rudolph, Renjie Song, Nicholas J Mantis

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. OspA antibodies inhibit theInfection and immunity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amber M FryeDepartment of Biomedical Sciences, University at Albany, Albany, New York, USA.
Monir EjemelMassBiologics, Boston, Massachusetts, USA.
Lisa CavaciniMassBiologics, Boston, Massachusetts, USA.
Yang WangMassBiologics, Boston, Massachusetts, USA.
Michael J RudolphNew York Structural Biology Centergrid.422632.3, New York, New York, USA.
Renjie SongDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Nicholas J MantisDepartment of Biomedical Sciences, University at Albany, Albany, New York, USA.ORCID 0000-0002-5083-8640
New York State Department of Health · USNew York Structural Biology Center · USUniversity at Albany, State University of New York · US

Funding

Tickborne Disease: B cell epitope discovery and mechanisms of antibody Protection75N93019C00040 · NIAID · NYSDOH/HEALTH RESEARCH, INC. · PI MANTIS, NICHOLAS J. · 2019 to 2023
$10.3M
NIAID NIH HHS 75N93019C00040
6 · The paper itself

Abstract

Lyme disease vaccines based on recombinant

Indexed as

Borrelia burgdorferiBorrelia burgdorferi GroupLyme DiseaseTicksAgglutinationAnimalsAntibodies, BacterialAntibodies, MonoclonalAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesEpitopesHumansImmune SeraImmunoglobulin Fab FragmentsLipoproteinsAntibodies, BacterialAntibodies, MonoclonalAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesEpitopesImmune SeraImmunoglobulin Fab FragmentsLipoproteinsLyme Disease VaccinesOspA proteinPropidiumantibodyprotectivespirochetevaccines

Identifiers

PMID36000876
PMCPMC9476992
OpenAlexW4293213930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.