Evidence map›Paper›PMID 36000845›Full record

ArticleJournal of virology2022

HLA-II-Associated HIV-1 Adaptation Decreases CD4

Jacob K Files, Sarah Sterrett, Sebastian Henostroza, Christopher Fucile, Kevin Maroney, Tim Fram, Simon Mallal, Spyros Kalams, Jonathan Carlson, Alexander Rosenberg and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Jacob K FilesDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.ORCID 0000-0003-4425-091X
Sarah SterrettDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Sebastian HenostrozaDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Christopher FucileInformatics Institute, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Kevin MaroneyDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Tim FramDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Simon MallalVanderbilt University Medical Center, Nashville, Tennessee, USA.
Spyros KalamsVanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0098-7995
Jonathan CarlsonMicrosoft Research, Microsoft, Redmond, Washington, USA.
Alexander RosenbergInformatics Institute, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Nathan ErdmannDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
Anju BansalDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.ORCID 0000-0002-8142-0386
Paul A GoepfertDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birminghamgrid.265892.2, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USMicrosoft (United States) · USMurdoch University · AUVanderbilt University Medical Center · US

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
A-Z Clinical Trials UnitUM1AI069452 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 2012 to 2026
$28.8M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
Defining the biological relevance of HIV-1 adaptation to CD4 T cell responsesR01AI134648 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOEPFERT, PAUL A. · 2017 to 2021
$3.5M
Impact of HLA-II Adaptation on CD4 T-cell and Tfh responses in HIV-1 VaccinationF30AI155295 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FILES, JACOB · 2021 to 2023
$124k
NIAID NIH HHS F30 AI155295NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI110527NIAID NIH HHS R01 AI134648NIAID NIH HHS UM1 AI069452
6 · The paper itself

Abstract

Epitopes with evidence of HLA-II-associated adaptation induce poorly immunogenic CD4

Indexed as

AIDS VaccinesAntibody FormationCD4-Positive T-LymphocytesEpitopes, T-LymphocyteHIV-1HIV InfectionsHLA-D AntigensImmune EvasionBroadly Neutralizing AntibodiesClinical Trials as TopicHIV AntibodiesHumansAIDS VaccinesBroadly Neutralizing AntibodiesEpitopes, T-LymphocyteHIV AntibodiesHLA-D AntigensCD4+ T-cell responsesHIVHIV vaccines

Identifiers

PMID36000845
PMCPMC9472760
OpenAlexW4293216543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.