Evidence map›Paper›PMID 36000449›Full record

ArticleEpigenetics2022

Context-dependent CpG methylation directs cell-specific binding of transcription factor ZBTB38.

Claire Marchal, Pierre-Antoine Defossez, Benoit Miotto

Open access · hybridAbstract read
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. DNA Methylation Variation in Blood Cells may Impact Platelet Function.TH open : companion journal to thrombosis and haemostasis · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The remodeling of Z-DNA in the mammalian germ line.Biochemical Society transactions · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Claire MarchalUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.ORCID 0000-0001-8253-2665
Pierre-Antoine DefossezUniversité Paris Cité, Epigenetics and Cell Fate, Paris, France.ORCID 0000-0002-6463-9263
Benoit MiottoUniversité Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France.ORCID 0000-0003-2857-2126
Centre National de la Recherche Scientifique · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation on CpGs regulates transcription in mammals, both by decreasing the binding of methylation-repelled factors and by increasing the binding of methylation-attracted factors. Among the latter, zinc finger proteins have the potential to bind methylated CpGs in a sequence-specific context. The protein ZBTB38 is unique in that it has two independent sets of zinc fingers, which recognize two different methylated consensus sequences

Indexed as

DNA MethylationTranscription FactorsAnimalsBinding SitesCpG IslandsGene Expression RegulationHumansMammalsProtein BindingRepressor ProteinsZinc FingersRepressor ProteinsTranscription FactorsZBTB38 protein, humanAlu repeatscell cycleDNA methylationE2F factorzinc finger protein ZBTB38

Identifiers

PMID36000449
PMCPMC9665152
OpenAlexW4293170966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.