Evidence map›Paper›PMID 36000422›Full record

ArticleJournal of the American Heart Association2022

Inflammatory Role of Milk Fat Globule-Epidermal Growth Factor VIII in Age-Associated Arterial Remodeling.

Leng Ni, Lijuan Liu, Wanqu Zhu, Richard Telljohann, Jing Zhang, Robert E Monticone, Kimberly R McGraw, Changwei Liu, Christopher H Morrell, Pablo Garrido-Gil and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Effects of GDF6 on active protein synthesis by cells of degenerated intervertebral disc.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Leng NiLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Lijuan LiuLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Wanqu ZhuLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Richard TelljohannLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Jing ZhangLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Robert E MonticoneLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Kimberly R McGrawLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Changwei LiuDepartment of Vascular Surgery, Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China.
Christopher H MorrellLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Pablo Garrido-GilResearch Center for Molecular Medicine and Chronic Diseases (CIMUS), IDIS University of Santiago de Compostela Spain.
Jose Luis Labandeira-GarciaResearch Center for Molecular Medicine and Chronic Diseases (CIMUS), IDIS University of Santiago de Compostela Spain.
Edward G LakattaLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
Mingyi WangLaboratory of Cardiovascular Science, National Institution on Aging National Institutes of Health, Biomedical Research Center (BRC) Baltimore MD.
National Institutes of Health · USBiomedical Research Networking Center on Neurodegenerative Diseases · ESChinese Academy of Medical Sciences & Peking Union Medical College · CNInstitute on Aging · USUniversidade de Santiago de Compostela · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Age-associated aortic remodeling includes a marked increase in intimal medial thickness (IMT), associated with signs of inflammation. Although aortic wall milk fat globule-epidermal growth factor VIII (MFG-E8) increases with age, and is associated with aortic inflammation, it is not known whether MFG-E8 is

Indexed as

Angiotensin IIEpidermal Growth FactorAnimalsGlycolipidsGlycoproteinsInflammationLipid DropletsMiceMice, KnockoutMilk ProteinsAngiotensin IIEpidermal Growth FactorGlycolipidsGlycoproteinsmilk fat globuleMilk Proteinsage‐associated aortic remodelingangiotensin II signalinginflammationintimal medial thickeningmilk fat globule–epidermal growth factor 8

Identifiers

PMID36000422
PMCPMC9496444
OpenAlexW4293171407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.