Evidence map›Paper›PMID 36000279›Full record

ArticleSoft matter2022

Zwitterionic surface chemistry enhances detachment of bacteria under shear.

Molly K Shave, Yitian Zhou, Jiwon Kim, Ye Chan Kim, Jaime Hutchison, Denis Bendejacq, Mark Goulian, Jonghoon Choi, Russell J Composto, Daeyeon Lee

Abstract read
In one paragraph

Article in Soft matter, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Molly K ShaveDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. composto@seas.upenn.edu.ORCID http://orcid.org/0000-0003-3660-2639
Yitian ZhouDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. composto@seas.upenn.edu.
Jiwon KimDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. composto@seas.upenn.edu.ORCID http://orcid.org/0000-0002-7412-161X
Ye Chan KimDepartment of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-5122-9716
Jaime HutchisonSolvay, Bristol, PA, USA.
Denis BendejacqSolvay, Bristol, PA, USA.
Mark GoulianDepartment of Biology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jonghoon ChoiDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. composto@seas.upenn.edu.
Russell J CompostoDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. composto@seas.upenn.edu.ORCID http://orcid.org/0000-0002-5906-2594
Daeyeon LeeDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. composto@seas.upenn.edu.ORCID http://orcid.org/0000-0001-6679-290X

Funding

Phosphorelay signaling and regulation in bacteriaR35GM139541 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM139541
6 · The paper itself

Abstract

The ubiquitous nature of microorganisms, especially of biofilm-forming bacteria, makes biofouling a prevalent challenge in many settings, including medical and industrial environments immersed in liquid and subjected to shear forces. Recent studies have shown that zwitterionic groups are effective in suppressing bacteria and protein adhesion as well as biofilm growth. However, the effect of zwitterionic groups on the removal of surface-bound bacteria has not been extensively studied. Here we present a microfluidic approach to evaluate the effectiveness in facilitating bacteria detachment by shear of an antifouling surface treatment using (3-(dimethyl;(3-trimethoxysilyl)propyl)ammonia propane-1-sulfonate), a sulfobetaine silane (SBS). Control studies show that SBS-functionalized surfaces greatly increase protein (bovine serum albumin) removal upon rinsing. On the same surfaces, enhanced bacteria (

Indexed as

Bacterial AdhesionBiofoulingBacteriaBetaineSurface PropertiesBetainesulfobetaine

Identifiers

PMID36000279
PMCPMC10838016

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.