Evidence map›Paper›PMID 36000230›Full record

ArticleJournal of the Royal Society, Interface2022

Lymphoedema conditions disrupt endothelial barrier function

Joshua D Hall, Sina Farzaneh, Reza Babakhani Galangashi, Akshay Pujari, Daniel T Sweet, Mark L Kahn, Juan M Jiménez

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joshua D HallDepartment of Mechanical and Industrial Engineering, University of Massachusetts Amherst, Amherst, MA, USA.
Sina FarzanehDepartment of Mechanical and Industrial Engineering, University of Massachusetts Amherst, Amherst, MA, USA.
Reza Babakhani GalangashiDepartment of Mechanical and Industrial Engineering, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0000-0002-1511-7637
Akshay PujariDepartment of Mechanical and Industrial Engineering, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0000-0002-7499-5122
Daniel T SweetDepartment of Medicine and Division of Cardiology, University of Pennsylvania, Philadelphia, PA, USA.
Mark L KahnDepartment of Medicine and Division of Cardiology, University of Pennsylvania, Philadelphia, PA, USA.
Juan M JiménezDepartment of Mechanical and Industrial Engineering, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0000-0002-3915-2883
University of Massachusetts Amherst · USUniversity of Pennsylvania · US

Funding

HEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1M
Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Control of lymphatic vessel growth and development by plateletsR01HL103432 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2010 to 2013
$1.6M
Improved stent design through hemodynamics and vascular biologyK25HL107617 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JIMENEZ, JUAN MIGUEL · 2012 to 2016
$770k
NHLBI NIH HHS K25 HL107617NHLBI NIH HHS R01 HL103432NHLBI NIH HHS T32 HL007439NIGMS NIH HHS T32 GM135096
6 · The paper itself

Abstract

Lymphatic vessel contractions generate net antegrade pulsatile lymph flow. By contrast, impaired lymphatic vessels are often associated with lymphoedema and altered lymph flow. The effect of lymphoedema on the lymph flow field and endothelium is not completely known. Here, we characterized the lymphatic flow field of a platelet-specific receptor C-type lectin-like receptor 2 (CLEC2) deficient lymphoedema mouse model. In regions of lymphoedema, collecting vessels were significantly distended, vessel contractility was greatly diminished and pulsatile lymph flow was replaced by quasi-steady flow.

Indexed as

Lymphatic VesselsLymphedemaAnimalsEndothelial CellsEndotheliumHumansLymphatic SystemMiceendothelial permeabilityfluid mechanicslymphaticslymphoedemamechanotransductionpulsatility

Identifiers

PMID36000230
PMCPMC9399713
OpenAlexW4293084507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.