ArticleThe American journal of psychiatry2023
The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers.
Erratum issuedAbstract read
In one paragraph
Article in The American journal of psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Oxytocin facilitates top-down and bottom-up attention to emotional faces in a general and temporal-dependent manner.Psychological medicine · 2026Trial
- A single-blind active-control randomized controlled trial of group-based social competence intervention.Scientific reports · 2025Trial
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Analysis of the Pupillary Light Reflex Response Against Light Stimuli for Autism Screening in Children.Journal of autism and developmental disorders · 2026Article
- Excitation/inhibition balance subtypes in autism and their genetic, neural, and clinical profiles.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Towards precision psychiatry: initial foundations and future directions.Nature reviews. Drug discovery · 2026Review
- Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis.Cell reports. Medicine · 2026Review
- Neural oscillatory dynamics reveal altered top-down and integrative mechanisms during face processing in autistic children and unaffected siblings of autistic children.Journal of neurodevelopmental disorders · 2026Article
- Measuring Accuracy (Classification Probabilities, Positive, and Negative Predictive Values) of Executive Function Electroencephalogram Metrics in Attention-Deficit/Hyperactivity Disorder Diagnosis: Protocol for and Perspectives From the SINCRONIA Study.JMIR research protocols · 2026Article
- Number of Alpha Peaks in the Electroencephalogram Is Associated With Clinical Phenotype and Copy Number Variants in Youths With Autism.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- How to Improve the Reliability of Aperiodic Parameter Estimates in M/EEG: A Method Comparison.Psychophysiology · 2026Article
- Reduced social prioritization: An underlying mechanism driving slower latency to look at faces in autism.Journal of psychopathology and clinical science · 2026Article
- Opposite sides of different coins: near-diametrical opposition of physiological indices of reduced accuracy of face emotion recognition in schizophrenia and autism spectrum disorders.Frontiers in neuroimaging · 2026Article
- Novel therapeutics in autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Multilevel Multivariate Functional Principal Component Analysis of Evoked and Induced Event-Related Spectral Perturbations.Statistics in biosciences · 2025Article
- Harnessing Trial-to-Trial Variability of EEG Spectral Characteristics to Understand Autism.Journal of autism and developmental disorders · 2025Article
- Genetic and environmental influences in autism: guiding the future of tailored early detection and intervention.The Journal of clinical investigation · 2025Article
- How to Improve the Reliability of Aperiodic Parameter Estimates in M/EEG: A Method Comparison and Recommendations for Best Practices.bioRxiv : the preprint server for biology · 2025Article
- Neural oscillatory dynamics reveal altered top-down and integrative mechanisms during face processing in autistic children and unaffected siblings of autistic children.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
24 authors.
Sara Jane WebbCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Adam J NaplesCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
April R LevinCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Gerhard HellemannCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Heather BorlandCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Jessica BentonCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Carter CarlosCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Takumi McAllisterCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Megha SanthoshCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Helen SeowCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Adham AtyabiCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Raphael BernierCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Katarzyna ChawarskaCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Geraldine DawsonCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
James DziuraCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Susan FajaCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Shafali JesteCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Michael MuriasCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Charles A NelsonCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Maura Sabatos-DeVitoCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Damla SenturkCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Frederick ShicCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Catherine A SugarCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
James C McPartlandCenter for Child Health, Behavior, and Development and Seattle Children's Research Institute, Seattle (Webb, Borland, Benton, Santhosh, Shic); Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle (Webb, Bernier); Yale Child Study Center (Naples, Carlos, McAllister, Chawarska, McPartland), Yale Center for Clinical Investigation (Seow), and Department of Emergency Medicine (Dziura), Yale University, New Haven, Conn.; Department of Neurology, Boston Children's Hospital, Boston (Levin); Department of Neurology, Harvard Medical School, Boston (Levin); Department of Psychiatry and Biobehavioral Sciences (Hellemann, Jeste, Senturk, Sugar) and Department of Biostatistics (Senturk, Sugar), University of California Los Angeles, Los Angeles; Department of Computer Science, University of Colorado, Colorado Springs (Atyabi); Duke Center for Autism and Brain Development (Dawson, Sabatos-DeVito) and Department of Psychiatry and Behavioral Sciences (Dawson), Duke University, Durham, N.C.; Department of Pediatrics, Harvard University, Boston (Faja, Nelson); Division of Developmental Medicine, Boston Children's Hospital, Boston (Faja, Nelson); Department of Medical Social Sciences, Northwestern University, Chicago (Murias); Graduate School of Education, Harvard University, Boston (Nelson); Department of Pediatrics, University of Washington, Seattle (Shic).
Funding
The Autism Biomarkers Consortium for Clinical TrialsU19MH108206 · NIMH · YALE UNIVERSITY · PI DZIURA, JAMES DAVID · 2015 to 2024
$68.8MMechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MBiomarker Qualification Plan Development for the N170 in Autism Spectrum DisorderU01FD006888 · FDA · YALE UNIVERSITY · PI MCPARTLAND, JAMES CHARLES · 2019 to 2019
$250kFDA HHS U01 FD006888NICHD NIH HHS P50 HD103524NICHD NIH HHS P50 HD105351NIMH NIH HHS U19 MH108206
Abstract
objectiveNumerous candidate EEG biomarkers have been put forward for use in clinical research on autism spectrum disorder (ASD), but biomarker development has been hindered by limited attention to the psychometric properties of derived variables, inconsistent results across small studies, and variable methodology. The authors evaluated the basic psychometric properties of a battery of EEG assays for their potential suitability as biomarkers in clinical trials.
methodsThis was a large, multisite, naturalistic study in 6- to 11-year-old children who either had an ASD diagnosis (N=280) or were typically developing (N=119). The authors evaluated an EEG battery composed of well-studied assays of resting-state activity, face perception (faces task), biological motion perception, and visual evoked potentials (VEPs). Biomarker psychometrics were evaluated in terms of acquisition rates, construct performance, and 6-week stability. Preliminary evaluation of use was explored through group discrimination and phenotypic correlations.
resultsThree assays (resting state, faces task, and VEP) show promise in terms of acquisition rates and construct performance. Six-week stability values in the ASD group were moderate (intraclass correlations ≥0.66) for the faces task latency of the P1 and N170, the VEP amplitude of N1 and P1, and resting alpha power. Group discrimination and phenotype correlations were primarily observed for the faces task P1 and N170.
conclusionsIn the context of a large-scale, rigorous evaluation of candidate EEG biomarkers for use in ASD clinical trials, neural response to faces emerged as a promising biomarker for continued evaluation. Resting-state activity and VEP yielded mixed results. The study's biological motion perception assay failed to display construct performance. The results provide information about EEG biomarker performance that is relevant for the next stage of biomarker development efforts focused on context of use.
Indexed as
Autism Spectrum DisorderAutistic DisorderBiomarkersClinical Trials as TopicElectroencephalographyEvoked Potentials, VisualHumansBiomarkersAutism Spectrum DisorderBiological MarkersNeurodevelopmental DisordersNeuroscience
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.