Evidence map›Paper›PMID 36000046›Full record

ArticleLaryngoscope investigative otolaryngology2022

Validation of a surgical training model containing indocyanine green for near-infrared fluorescence imaging.

Naoki Nishio, Sohei Mitani, Kayo Sakamoto, Gaku Morimoto, Sayaka Yokoi, Mayu Shigeyama, Akihisa Wada, Nobuaki Mukoyama, Eben L Rosenthal, Michihiko Sone

Open access · goldAbstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Naoki NishioDepartment of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Aichi Japan.ORCID https://orcid.org/0000-0003-1495-0376
Sohei MitaniDepartment of Otolaryngology-Head and Neck Surgery Ehime University Graduate School of Medicine Toon Ehime Japan.
Kayo SakamotoDepartment of Otolaryngology-Head and Neck Surgery Ehime University Graduate School of Medicine Toon Ehime Japan.
Gaku MorimotoKOTOBUKI Medical Inc Yashio Saitama Japan.
Sayaka YokoiDepartment of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Aichi Japan.
Mayu ShigeyamaDepartment of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Aichi Japan.
Akihisa WadaDepartment of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Aichi Japan.
Nobuaki MukoyamaDepartment of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Aichi Japan.
Eben L RosenthalDepartment of Otolaryngology-Head and Neck Surgery Vanderbilt University Medical Center Nashville Tennessee USA.
Michihiko SoneDepartment of Otorhinolaryngology Nagoya University Graduate School of Medicine Nagoya Aichi Japan.ORCID https://orcid.org/0000-0001-7380-610X
Nagoya University · JPEhime University · JPSaitama Medical University · JPVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine the efficacy of a surgical training model for fluorescence-guided cancer surgery and validate its utility to detect any residual tumors after tumor resection using electrocautery. Methods: We developed surgical training models containing indocyanine green (ICG) for near-infrared (NIR) fluorescence imaging using a root vegetable organic material (konjac). After the fluorescence assessment for the models, the surgical simulation for fluorescence-guided cancer surgery using electrocautery was performed. ICG-containing tumors were divided into two surgical groups: "Enucleation" (removal of the entire visible tumor) and "Complete resection" (removal of the tumor with an appropriate 5-mm surgical margin). Results: All 12 ICG-containing tumors were clearly visible from the normal view but not from the flipped view. The tumor resection time was significantly longer in the "Complete resection" group than in the "Enucleation" group ( Conclusion: Our surgical training model containing a fluorescent agent is safe, inexpensive, not harmful for humans, and easy to dispose after use. Our model would be beneficial for surgeons to learn NIR fluorescence imaging and to accelerate fluorescence-guided cancer surgery into clinical application.

Indexed as

electrocauteryfluorescence‐guided surgeryindocyanine greennear‐infrared fluorescence imagingsurgical training

Identifiers

PMID36000046
PMCPMC9392384
OpenAlexW4284895814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.