ArticleLaryngoscope investigative otolaryngology2022
Histopathological characteristics of larynx in hypothyroidism in an experimental rabbit model.
Article in Laryngoscope investigative otolaryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Effects of Hypothyroidism on the Extracellular Matrix of the Vocal Folds of Adult Female Rats.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Article
- Histopathological characteristics of larynx in hypothyroidism in an experimental rabbit model.Laryngoscope investigative otolaryngology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Hypothyroidism has a significant effect on the patients' voices. This study evaluated the histopathological characteristics of larynx following hypothyroidism in an experimental rabbit model. Methods: Eleven male Dutch rabbits were included. Methimazole-induced hypothyroidism was done for nine rabbits. The remaining two rabbits were assigned as controls. Six weeks after starting methimazole, a histological examination was performed with parameters of inflammation, ulceration, hemorrhage, and thickness of epithelium, Reinke's space, vocal ligament, thyroarytenoid muscle, collagen deposition, and periodic acid-Schiff (PAS)-positive materials, as well as confirmation of hypothyroidism by T4 measurement. Results: Histologic examination showed a significant thickening of epithelium, Reinke's space, vocal ligament, and collagen PAS-positive materials deposition in hypothyroid rabbits ( Conclusion: Hypothyroidism causes significant changes in the laryngeal tissues. Thickening of epithelium, Reinke's space, vocal ligament, collagen, PAS-positive materials, and reduced thickness of thyroarytenoid muscle are the major findings of this study.
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