Evidence map›Paper›PMID 35999710›Full record

SynthesisThyroid : official journal of the American Thyroid Association2022

Assessing Bias and Limitations of Clinical Validation Studies of Molecular Diagnostic Tests for Indeterminate Thyroid Nodules: Systematic Review and Meta-Analysis.

Catherine DiGennaro, Vahab Vahdatzad, Mohammad S Jalali, Asmae Toumi, Tina Watson, G Scott Gazelle, Nathaniel Mercaldo, Carrie Cunningham Lubitz

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Thyroid : official journal of the American Thyroid Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Molecular Diagnostics and [Thyroid : official journal of the American Thyroid Association · 2024
    Trial
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  3. Medullary thyroid carcinoma diagnosis based on microRNA analysis: a case report.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Observational
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Catherine DiGennaroInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-9452-6000
Vahab VahdatzadInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-7831-7567
Mohammad S JalaliInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-6769-2732
Asmae ToumiInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-6547-4747
Tina WatsonInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.
G Scott GazelleInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nathaniel MercaldoInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.
Carrie Cunningham LubitzInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts, USA.
Massachusetts General Hospital · US

Funding

Thyroid Nodule Treatment Optimization: A Personalized ApproachR37CA231957 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CUNNINGHAM, CARRIE ELIZABETH · 2019 to 2025
$3.6M
NCI NIH HHS R37 CA231957
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Thyroid NeoplasmsThyroid NoduleBiasBiopsy, Fine-NeedleHumansMolecular Diagnostic TechniquesPathology, Molecularbias assessmentclinical validitydiagnostic testsmeta-analysismolecular diagnosticsoncologysystematic reviewthyroid cancer

Identifiers

PMID35999710
PMCPMC9595633
OpenAlexW4292876320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.