ArticleParasites & vectors2022
First evidence of vertical Hepatozoon canis transmission in dogs in Europe.
Article in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Hemoparasites of the Four-Eyed Frog (Pleurodema thaul) From Chile.Integrative zoology · 2026Article
- Eco-epidemiology ofInternational journal for parasitology. Parasites and wildlife · 2026Article
- Challenging the Clinical Paradigm of Hepatozoon canis: A Primary Pathogen Causing Clinically Significant Disease at Low Parasitaemia and a Chronic Inflammatory State.Veterinary medicine and science · 2026Article
- A case of suspected vertical hepatozoonosis manifesting as severe anemia and gastroenteritis in a three-month-old puppy following vaccination.Veterinary research communications · 2026Article
- Ticks and Tick-Borne Microorganisms in Australian Wildlife: A Scoping One Health Evidence Synthesis of Reported Associations and Knowledge Gaps.Pathogens (Basel, Switzerland) · 2026Review
- A Molecular Epidemiological Survey of Tick-Borne Pathogens in Dogs and Their Associated Ticks in Xinjiang, China.Animals : an open access journal from MDPI · 2026Article
- Morphological and molecular detection of Hepatozoon species in amphibians and reptiles from Mato Grosso, Midwest Brazil.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Article
- Mass spectrometry-based serum peptidomic profiling reveals potential biomarker for canine hepatozoonosis.Scientific reports · 2025Article
- Hepatozoon infections in domestic and wild Carnivora: etiology, prevalence, clinical disease, diagnosis and treatment, and redescription of Hepatozoon silvestris, H. martis, and H. ursi.Parasites & vectors · 2025Review
- High prevalence of vector-borne protozoa and bacteria in dogs from Chad determined using a targeted next-generation sequencing approach.Scientific reports · 2025Article
- Host switching is the main driver of coevolution between Hepatozoon parasites and their vertebrate hosts.Parasites & vectors · 2025Article
- Diversity of ticks and tick-borne pathogens in ticks removed from dogs and cats: a focus on Poland, Czech Republic, Slovakia, Hungary, and Romania.Parasites & vectors · 2025Article
- Surveillance of tick-borne pathogens in domestic dogs from Chad, Africa.BMC veterinary research · 2024Article
- High serological and molecular prevalence of Ehrlichia canis and other vector-borne pathogens in dogs from Boa Vista Island, Cape Verde.Parasites & vectors · 2024Article
- A review of Hepatozoonosis caused byJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Review
- Endoparasitic Diseases in Breeding Kennels: A Frequent and Complex Problem Requiring a Holistic Approach.Animals : an open access journal from MDPI · 2024Review
- Molecular Detection and Genetic Variability ofBiology · 2024Article
- Molecular survey on vector-borne pathogens in clinically healthy stray cats in Zaragoza (Spain).Parasites & vectors · 2023Article
- Molecular Survey ofVeterinary sciences · 2023Article
- The first report on Hepatozoon canis in dogs and wolves in Poland: clinical and epidemiological features.Parasites & vectors · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatozoon canis is a protozoal agent that is known to be transmitted by oral uptake of H. canis-infected Rhipicephalus sanguineus sensu lato ticks in dogs. Vertical transmission of H. canis has only been described once in a study evaluating dogs from Japan. The aim of this study was to investigate the parasitological status of puppies from a bitch that had tested positive for Hepatozoon spp. prior to giving birth.
findingsA 4-year-old, female, pregnant dog imported from Italy (Sardinia) to Germany showed clinical signs of lethargy and tachypnoea and tested positive for H. canis by PCR. The dog gave birth to eight puppies, one of which was stillborn and another that had to be reanimated. Haematology, buffy coat analysis and a biochemistry profile were performed for each dog. EDTA-blood of the surviving seven puppies and bone marrow, liver, spleen, amniotic fluid, and umbilical cord of the stillborn puppy was tested for the presence of Hepatozoon spp. by PCR. The mother and the seven surviving puppies tested positive for H. canis by PCR at day 62 post-partum. Gamonts were detected in all dogs by buffy coat evaluation. Haematological and biochemistry results revealed mild abnormalities. In the stillborn puppy, spleen, umbilical cord, and amniotic fluid were positive for H. canis.
conclusionThe results confirm that vertical transmission is a possible route of H. canis infection in dogs, demonstrated by molecular detection of the pathogen in the stillborn puppy. In the seven surviving puppies, vertical transmission was the most likely transmission route. A potential impact of the level of parasitaemia on the health of puppies, as well as its pathogenesis, should be investigated further.
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