Evidence map›Paper›PMID 35999584›Full record

ArticleCancer cell international2022

Antitumor immunity and therapeutic properties of marine seaweeds-derived extracts in the treatment of cancer.

Mostafa M El-Sheekh, Mohamed Nassef, Eman Bases, Shimaa El Shafay, Rania El-Shenody

Abstract read
In one paragraph

Article in Cancer cell international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Journal of Taibah University Medical Sciences · 2024
    Article
  7. Article
  8. The Ocean's Pharmacy: Health Discoveries in Marine Algae.Molecules (Basel, Switzerland) · 2024
    Review
  9. Article
  10. Antiviral Activity ofCurrent topics in medicinal chemistry · 2024
    Article
  11. Article
  12. Modulation of toxicity effects of CuSOScientific reports · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Perspectives for the Use of Fucoidans in Clinical Oncology.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mostafa M El-SheekhBotany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt. mostafaelsheikh@science.tanta.edu.eg.
Mohamed NassefZoology Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Eman BasesBotany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Shimaa El ShafayBotany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Rania El-ShenodyBotany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine seaweeds are important sources of drugs with several pharmacological characteristics. The present study aims to evaluate the antitumor and antitumor immunological potentials of the extracts from the brown alga Padina pavonica and the red alga Jania rubens, inhibiting the Egyptian marine coasts. Hep-G2 cell lines were used for assessment of the antitumor efficacy of Padina pavonica and Jania rubens extracts in vitro, while Ehrlich ascites carcinoma (EAC) cells were applied to gain more antitumor immunity and antitumor insights of P. pavonica and J. rubens extracts in vivo. In vitro antitumor potentials of P. pavonica and J. rubens extracts were analyzed against human liver cancer Hep-G2 cells by MTT and trypan blue exclusion assays. In vivo antitumor immunological potentials of P. pavonica and J. rubens extracts at low, high, and prophylactic doses were analyzed by blood counting and flow cytometry in mice challenged with Ehrlich ascites carcinoma (EAC) cells. In vitro results revealed that P. pavonica and J. rubens extracts caused significant decreases in the number and viability of Hep-G2 cells in a dose-dependent manner as compared to untreated Hep-G2 cells or Cisplatin

Indexed as

Antitumor immunityApoptosisImmunomodulationSeaweeds

Identifiers

PMID35999584
PMCPMC9396856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.