ArticleParasites & vectors2022
Novel Ehrlichia canis genogroup in dogs with canine ehrlichiosis in Cuba.
Article in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Genetic variants of Ehrlichia canis detected in two dogs in Japan.Veterinary research communications · 2026Article
- Molecular Characterization and Genetic Diversity of Ehrlichia canis in Naturally Infected Dogs from the Unaí Microregion, Minas Gerais, Brazil.Acta parasitologica · 2026Article
- Occurrence, Risk Factors, and Molecular Characterization ofVeterinary sciences · 2026Article
- High genetic diversity of Ehrlichia canis trp36 and p28 genes in dogs from Rio de Janeiro, Brazil.Veterinary research communications · 2025Article
- Review
- Epidemiology of canine ehrlichiosis and molecular characterization of Erhlichia canis in Bangladeshi pet dogs.PloS one · 2024Article
- Molecular occurrence and genetic diversity of Ehrlichia canis in naturally infected dogs from Thailand.Scientific reports · 2023Article
- Costa Rican Genotype ofVeterinary sciences · 2023Article
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Authors and funding
16 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundCanine monocytic ehrlichiosis (CME) is caused by the tick-borne pathogen Ehrlichia canis, an obligate intracellular Gram-negative bacterium of the family Anaplasmataceae with tropism for canine monocytes and macrophages. The trp36 gene, which encodes for the major immunoreactive protein TRP36 in E. canis, has been successfully used to characterize the genetic diversity of this pathogen in different regions of the world. Based on trp36 sequence analysis, four E. canis genogroups, United States (US), Taiwan (TWN), Brazil (BR) and Costa Rica (CR), have been identified. The aim of this study was to characterize the genetic diversity of E. canis in Cuba based on the trp36 gene.
methodsWhole blood samples (n = 8) were collected from dogs found to be infested with the tick vector Rhipicephalus sanguineus sensu lato (s.l.) and/or presenting clinical signs and symptoms of CME. Total DNA was extracted from the blood samples and trp36 fragments were amplified by PCR. Nucleotide and protein sequences were compared using alignments and phylogenetic analysis.
resultsFour of the trp36 sequences obtained (n = 8) fall within the phylogenetic cluster grouping the US genogroup E. canis strains. The other E. canis trp36 sequences formed a separate and well-supported clade (94% bootstrap value) that is phylogenetically distant from the other major groups and thus represents a new genogroup, herein designated as the 'Cuba (CUB) genogroup'. Notably, dogs infected with the CUB genogroup presented frequent hemorrhagic lesions.
conclusionsThe results of this study suggest that genetic diversification of E. canis in Cuba is associated with the emergence of E. canis strains with increased virulence.
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