Evidence map›Paper›PMID 35999547›Full record

ArticleJournal of nanobiotechnology2022

Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing.

Qiqi Liu, Ying Zhang, Jingkai Huang, Zhourui Xu, Xiang Li, Jingyu Yang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Jinbo Lin and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Arginine-loaded silica nanoparticles inhibit E. faecalis in root canals.Journal of materials science. Materials in medicine · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Immunomodulatory Delivery Materials for Tissue Repair.Advanced healthcare materials · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Nanotechnology-based mRNA vaccines.Nature reviews. Methods primers · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Qiqi Liu *Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Ying Zhang *Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Jingkai HuangDermatology Department, Southern University of Science and Technology Hospital (SUSTech Hospital), Shenzhen, 518055, China.
Zhourui XuGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Xiang LiGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Jingyu YangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Haoqiang HuangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Shiqi TangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Yujuan ChaiGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
Jinbo LinCentral Laboratory, The Second Affiliated Hospital, School of Medicine, Longgang District People's Hospital of Shenzhen, The Chinese University of Hong Kong, Shenzhen, 518172, China.
Chengbin YangGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China. cbyang@szu.edu.cn.
Jia LiuCentral Laboratory, The Second Affiliated Hospital, School of Medicine, Longgang District People's Hospital of Shenzhen, The Chinese University of Hong Kong, Shenzhen, 518172, China. liujia870702@126.com.
Suxia LinCenter of Assisted Reproduction and Embryology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518048, China. linsx@hku-szh.org.
Shenzhen University Health Science Center · CNChinese University of Hong Kong, Shenzhen · CNSouthern University of Science and Technology · CNUniversity of Hong Kong · HK

Funding

National Natural Science Foundation of China 81900264Start-up Grant from Shenzhen University 2019136the Longgang Medical and Health Science and Technology Project LGKCYLWS2020040the Natural Science Foundation of Guangdong Province 2019A1515012163the Shenzhen Science and Technology Innovation Commission JCYJ20210324130609027the University Stable Support Research Funding of Shenzhen 20200813153346001
6 · The paper itself

Abstract

The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core-shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based nanoplatform was elaborately fabricated to co-load ciprofloxacin (CFL) and tumor necrosis factor-α (TNF-α) small interfering RNA (siTNF-α) (AMPC@siTNF-α) for treating the bacterial-infected wound. The growth of bacterial pathogens was mostly inhibited by released silver ions (Ag

Indexed as

Metal NanoparticlesWound InfectionAnimalsAnti-Bacterial AgentsCiprofloxacinEscherichia coliMiceRNA, Small InterferingSilicon DioxideSilverTumor Necrosis Factor-alphaWound HealingAnti-Bacterial AgentsCiprofloxacinRNA, Small InterferingSilicon DioxideSilverTumor Necrosis Factor-alphaAntibacterialMesoporous silicasiRNASkin infectionSynergistic therapyWound healing

Identifiers

PMID35999547
PMCPMC9400313
OpenAlexW4292723043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.