Evidence map›Paper›PMID 35999464›Full record

ReviewAesthetic plastic surgery2023

Safety and Efficiency of Minimally Invasive Buttock Augmentation: A Review.

Bishara Atiyeh, Fadi Ghieh, Ahmad Oneisi

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Aesthetic plastic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06851494 (Safety and Efficacy of Linnea Safe PMMA 30% Use for Gluteal Augmentation.), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06851494 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Safety and Efficacy of Linnea Safe PMMA 30% Use for Gluteal Augmentation.

TypeinterventionalSponsorLEBON PRODUTOS QUIMICOS E FARMACEUTICOS LTDA.Ran2025 to 2026Enrolled137ConditionsGluteal AugmentationArmsPMMA
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Hyaluronic Acid Gluteal Augmentation: New Marking and Application Technique.Plastic and reconstructive surgery. Global open · 2025
    Article
  4. Aquafilling Filler for Buttock Augmentation Cause Severe Long-Term Complications: A Case Report.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2025
    Article
  5. Article
  6. Management of AQUAfilling® Filler Application Complications.Sisli Etfal Hastanesi tip bulteni · 2025
    Article
  7. Article
  8. Fatal pulmonary embolism following injectable gluteal filler usage: a case report.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Article
  9. Long-term Complications of Gluteal Augmentation Using Aquafilling Filler: A Case Report.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bishara AtiyehDivision of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
Fadi GhiehDivision of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
Ahmad OneisiDivision of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon. oneisi.ahmad@gmail.com.ORCID http://orcid.org/0000-0002-5423-1459
American University of Beirut Medical Center · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVolume restoration and enhancement of the gluteal region appearance has become nowadays a popular concern in particular for many women. Several options are available, none however are without complications and side effects. Volume enhancement with soft tissue fillers of the gluteal region is emerging as a highly attractive minimally invasive modality. It has led unfortunately to more unlicensed, nonmedical practitioners administering illicitly injections for buttock augmentation at relatively low costs. MATERIALS AND

methodsTo determine safety, efficacy, and cost effectiveness of mostly used soft-tissue fillers for buttock augmentation, a systematic literature search of PubMed, Medline, and Embase was conducted to identify the mostly used fillers for gluteal augmentation. It was complemented by searching for each of the identified filler material separately to retrieve any missed reports. References of clinical studies and trials, reviews, and consensus reports were reviewed as well for the same objective.

resultsIn the final analysis 12, mostly strongly biased clinical reports providing a low level of evidence, were identified for inclusion in the review. Two studies involved Polymethylmethacrylate (PMMA), 5 Poly-L-lactic acid, 1 Calcium hydroxyapatite and 4 hyaluronic acid filler injection. No studies were identified involving liquid silicone or Polyacrylamide hydrogel. The little available evidence provided by this review indicates that a specific brand of PMMA in Brazil has a demonstrable relatively good safety, efficiency, and cost-effectiveness record superior to surgical alloplastic gluteal augmentation or to lipofilling only when injected by experts.

conclusionGluteal augmentation with soft tissue fillers is not as simple and innocuous as advertised. Serious complications may occur. Moreover, optimal buttock contouring entails not only volume augmentation but also volume removal; thus, volume augmentation with soft tissue fillers may not be ideal. Popularizing this modality must also be approached with great care. Serious complications do occur; they become inevitable when performed illegally by non-specialized, non-authorized, and unscrupulous practitioners in non-accredited facilities. Patients must be warned that adherence to regulations is critical and that only well-trained certified experts practicing legally in accredited facilities can address safely and efficiently their concerns. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Cosmetic TechniquesDermal FillersDrug-Related Side Effects and Adverse ReactionsButtocksFemaleHumansHyaluronic AcidInjections, SubcutaneousPolymethyl MethacrylateDermal FillersHyaluronic AcidPolymethyl MethacrylateButtock augmentationButtock enhancementInjectable fillerPolymethylmethacrylateSoft tissue filler

Identifiers

PMID35999464
OpenAlexW4292849370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.