Evidence map›Paper›PMID 35999441›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2023

Relationship Between Number of Oocytes Retrieved and Embryo Euploidy Rate in Controlled Ovarian Stimulation Cycles.

Jonathan D Buerger, Jitesh Datla, Shahab Minassian, Sarah Dreibelbis, Michael J Glassner, John J Orris, Nicolle Clements, Alyssa Sheffy, Sharon H Anderson

Open access · hybridFull text read
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jonathan D BuergerTower Health Reading Hospital, West Reading, PA, USA. Jonathan.buerger@towerhealth.org.ORCID 0000-0002-9291-7478
Jitesh DatlaSaint Joseph's University, Philadelphia, PA, USA.
Shahab MinassianTower Health Reading Hospital, West Reading, PA, USA.
Sarah DreibelbisTower Health Reading Hospital, West Reading, PA, USA.
Michael J GlassnerMain Line Fertility Center, Bryn Mawr, PA, USA.
John J OrrisMain Line Fertility Center, Bryn Mawr, PA, USA.
Nicolle ClementsSaint Joseph's University, Philadelphia, PA, USA.
Alyssa SheffyMain Line Fertility Center, Bryn Mawr, PA, USA.
Sharon H AndersonMain Line Fertility Center, Bryn Mawr, PA, USA.
Main Line Fertility · USReading Hospital · USSaint Joseph's University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This cohort study is aimed to determine if higher number of oocytes retrieved affects the rate of euploidy in the embryos of women undergoing controlled ovarian stimulation (COS) for in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A). A negative trend between the number of oocytes retrieved and embryo euploidy rate was observed using Visual Analytics software, especially when a higher number of oocytes were retrieved. After regression analysis, patient age was the only variable found to have a statistically significant negative effect (p < 0.0001) on euploidy rate in all regression models. Number of oocytes retrieved was not found to have a statistically significant effect on euploidy rate when analyzed per number of biopsied blastocysts (p = 0.5356), per number of oocytes retrieved (p = 0.1025), and per number of fertilized oocytes (p = 0.7241). The parameter estimates in the linear regression models were negative for number of oocytes retrieved. This study shows a statistically significant effect between patient age and embryo euploidy rate, which is already known. There is some evidence to suggest that higher number of oocytes retrieved may negatively impact the number of euploid embryos per number of oocytes retrieved based on the visual analytic graphs, p value approaching significance, and the negative parameter estimates in the regression models.

Indexed as

Preimplantation DiagnosisAneuploidyBlastocystCohort StudiesFemaleFertilization in VitroGenetic TestingHumansOocytesOvulation InductionPregnancyRetrospective StudiesControlled ovarian stimulationEuploid embryosIn vitro fertilizationPreimplantation genetic testing for aneuploidyRetrieved oocytes

Identifiers

PMID35999441
PMCPMC10014778
OpenAlexW4292800954

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read10
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.