Evidence map›Paper›PMID 35999337›Full record

ArticleGeroScience2022

Old plasma dilution reduces human biological age: a clinical study.

Daehwan Kim, Dobri D Kiprov, Connor Luellen, Michael Lieb, Chao Liu, Etsuko Watanabe, Xiaoyue Mei, Kaitlin Cassaleto, Joel Kramer, Michael J Conboy and 1 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Research progress on blood therapy for anti-aging.Journal of advanced research · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Misalignment of age clocks.GeroScience · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Daehwan KimDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Dobri D Kiprov *Global Apheresis, Mill Valley, CA, USA.
Connor Luellen *Biophysics, University of California, Berkeley, Berkeley, CA, 94720, USA.
Michael LiebDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Chao LiuDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Etsuko WatanabeDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Xiaoyue MeiDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Kaitlin CassaletoBrain Aging Center, UCSF, San Francisco, USA.
Joel KramerBrain Aging Center, UCSF, San Francisco, USA.
Michael J ConboyDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA.
Irina M ConboyDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, CA, 94720, USA. iconboy@berkeley.edu.
University of California, Berkeley · USQB3 · US

Funding

Identifying signatures of brain aging through heterochronic blood exchangeR01AG071787 · NIA · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MESSERSMITH, PHILLIP B, MOURRAIN, PHILIPPE · 2021 to 2025
$2.3M
New Generation Blood Exchange Devices for Enhancing Tissue Regeneration and HealthR01HL139605 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ARAN, KIANA, CONBOY, IRINA M · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL139605NIA NIH HHS R01 AG071787
6 · The paper itself

Abstract

This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice, human aging is driven by age-imposed systemic molecular excess, the attenuation of which reverses biological age, defined in our work as a deregulation (noise) of 10 novel protein biomarkers. The results on biological age are strongly supported by the data, which demonstrates that rounds of therapeutic plasma exchange (TPE) promote a global shift to a younger systemic proteome, including youthfully restored pro-regenerative, anticancer, and apoptotic regulators and a youthful profile of myeloid/lymphoid markers in circulating cells, which have reduced cellular senescence and lower DNA damage. Mechanistically, the circulatory regulators of the JAK-STAT, MAPK, TGF-beta, NF-κB, and Toll-like receptor signaling pathways become more youthfully balanced through normalization of TLR4, which we define as a nodal point of this molecular rejuvenation. The significance of our findings is confirmed through big-data gene expression studies.

Indexed as

NF-kappa BSignal TransductionAgingAnimalsCellular SenescenceHumansMiceTransforming Growth Factor betaNF-kappa BTransforming Growth Factor betaAgingBiological noiseLymphoid/myeloid markersPlasmapheresisProteomicsRejuvenation

Identifiers

PMID35999337
PMCPMC9398900
OpenAlexW4292851091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.