ArticleScientific reports2022
Allograft versus autograft for reconstruction after resection of primary bone tumors: a comparative study of long-term clinical outcomes and risk factors for failure of reconstruction.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Pathological fracture of primary lymphoma of bone: A case report on diagnosis and novel surgical management.Oncology letters · 2026Article
- Risk factors for implant-associated infection after bone allograft reconstruction: a 20-year retrospective cohort study.Archives of orthopaedic and trauma surgery · 2026Article
- Bridging the Gap: Biological Reconstruction with Vascularised Fibula, Massive Allograft, or Capanna Technique After Intercalary Resection in Children and Young Adults with Lower Limb Bone Sarcoma.Children (Basel, Switzerland) · 2026Review
- [Research progress on medial support augmentation techniques for proximal humeral fractures].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Advancements in Skeletal Tumour Management: Linking Metastatic Biology With Surgical Reconstruction.Cureus · 2026Review
- Anterolateral approach for benign proximal femoral lesions among Indian children.Bioinformation · 2026Article
- Current Strategies for Limb Salvage and Reconstruction in Pediatric Lower Extremity Malignant Bone Tumors: Focus on Growth Preservation and Functional Outcomes.Children (Basel, Switzerland) · 2025Review
- Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2025Review
- Digitally Designed Bone; A 3D-patient-specific Allograft Shelf for Severe Adolescent Hip Dysplasia: From Digital Design to Clinical Reality-A Conceptual Case Report.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Influence of load-bearing angle, structural topology, and porosity gradient on the energy absorption capability of TPMS-based scaffolds for bone tissue engineering.Frontiers in bioengineering and biotechnology · 2025Article
- Graft Infections in Biologic Reconstructions in the Oncologic Setting: A Systematic Review of the Literature.Journal of clinical medicine · 2024Review
- Fresh Fractures: A New Indication for Use of Bone Allografts-A 10-Year Data Analysis.Indian journal of orthopaedics · 2023Article
- Biological aspects to enhance fracture healing.EFORT open reviews · 2023Review
- Application of 3D Printing in Bone Grafts.Cells · 2023Review
- Complications of patients with bone tumors treated with carbon-fiber plates: an international multicenter study.Scientific reports · 2022Article
- Covalent immobilization of VEGF on allogeneic bone through polydopamine coating to improve bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been no studies comparing the outcomes of nonvascularized autograft (NA) and allograft after resection of primary bone tumors. This study compares the clinical, functional outcomes of NA and allograft reconstruction and analyzes the risk factors for failure after these procedures. A retrospective study of patients with primary bone tumors of the extremities who underwent NA (n = 50) and allograft reconstruction (n = 47). The minimum follow up time was 24 months. The mean time to union for the NA and allograft group was 9.8 ± 2.9 months and 11.5 ± 2.8 months, respectively (p = 0.002). Reconstruction failure in the NA and allograft group was 19 (38%) and 26 (55.3%), respectively. Nonunion (30%) was the most common complication found in the NA group, while structural failure (29.8%) was the most common in the allograft group. There was no significant difference in functional outcome in terms of the mean Musculoskeletal Tumor Society score between the NA and allograft groups (23.5 ± 2.8 and 23.9 ± 2.1, respectively, p = 0.42). Age, sex, tumor location, graft length, method of reconstruction did not significantly influence failure of reconstruction. Chemotherapy was the only significant risk factor affecting outcomes (HR = 3.49, 95% CI = 1.59-7.63, p = 0.002). In the subgroup analysis, the use of chemotherapy affected graft-host nonunion (p < 0.001) and structural failure in both the NA and allograft groups (p = 0.02). Both NA and allograft reconstruction methods provide acceptable clinical and functional outcomes. Chemotherapy is a risk factor for failure of both reconstructions, particularly graft-host nonunion and structural failure.
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