ArticleNature communications2022
Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genetic diversity and clinical spectrum ofIJID regions · 2026Article
- Comparative genomics and molecular insights into smooth and rough clinical isolates ofMicrobial genomics · 2026Article
- Genomic population structure, antimicrobial susceptibility, and clinical features ofJournal of clinical microbiology · 2026Article
- Global lineages of non-tuberculous mycobacteria in residential water samples from Germany.BMC microbiology · 2025Article
- Comparative Analysis of Evolutionary Distances Using the GenusInternational journal of molecular sciences · 2025Article
- Genomic insights into the plasmidome of non-tuberculous mycobacteria.Genome medicine · 2025Article
- NGS-based approach for diagnostically unidentifiedFrontiers in cellular and infection microbiology · 2025Article
- Cluster ofFrontiers in veterinary science · 2025Article
- Review
- Population genetic analysis of clinicalFrontiers in cellular and infection microbiology · 2024Article
- Genome-Scale Characterization ofInternational journal of molecular sciences · 2023Article
- The problem of Mycobacterium abscessus complex: multi-drug resistance, bacteriophage susceptibility and potential healthcare transmission.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023Article
- The small non-coding RNA B11 regulates multiple facets of Mycobacterium abscessus virulence.PLoS pathogens · 2023Article
- Epidemiological Investigation of Hospital Transmission of Corynebacterium striatum Infection by Core Genome Multilocus Sequence Typing Approach.Microbiology spectrum · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium abscessus is an emerging multidrug-resistant non-tuberculous mycobacterium that causes a wide spectrum of infections and has caused several local outbreaks worldwide. To facilitate standardized prospective molecular surveillance, we established a novel core genome multilocus sequence typing (cgMLST) scheme. Whole genome sequencing data of 1991 isolates were employed to validate the scheme, re-analyze global population structure and set genetic distance thresholds for cluster detection and taxonomic identification. We confirmed and amended the nomenclature of the main dominant circulating clones and found that these also correlate well with traditional 7-loci MLST. Dominant circulating clones could be linked to a corresponding reference genome with less than 250 alleles while 99% of pairwise comparisons between epidemiologically linked isolates were below 25 alleles and 90% below 10 alleles. These thresholds can be used to guide further epidemiological investigations. Overall, the scheme will help to unravel the apparent global spread of certain clonal complexes and as yet undiscovered transmission routes.
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