ReviewEpilepsia2022
Rescue therapies for seizure clusters: Pharmacology and target of treatments.
Review in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Recommendations for the community-based management of prolonged convulsive seizures in children in Europe.BMC pediatrics · 2026Guideline
- Short-Term Impact of Seizures and Mitigation Opportunities.Current neurology and neuroscience reports · 2024Pooled it
- Trial
- Potential for Therapeutic Alteration of the Underlying Biology of Epilepsy.Biomedicines · 2025Review
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- Medications used for seizure-emergency management in the UK community: A clinical practice research datalink retrospective database study.Epilepsia open · 2025Article
- Exploring proposed recommendations for immediate-use seizure medication: Treating both cluster and prolonged seizures with diazepam nasal spray.Epilepsia open · 2025Review
- Benzodiazepine rescue medication administration for seizure clusters: Real-world retrospective outcomes.Epilepsia · 2025Article
- Development of a novel dosing paradigm to model diazepam rescue therapy in preclinical seizure and epilepsy models.Epilepsia open · 2024Article
- Benzodiazepines for the Treatment of Seizure Clusters.CNS drugs · 2024Review
- Immediate Treatment of Seizure Clusters: A Conceptual Roadmap to Expedited Seizure Management.Neuropsychiatric disease and treatment · 2024Review
- Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs.Paediatric drugs · 2024Review
- Treatment of Seizure Clusters in Epilepsy: A Narrative Review on Rescue Therapies.Neurology and therapy · 2023Review
- Individualized Seizure Cluster Prediction Using Machine Learning and Chronic Ambulatory Intracranial EEG.IEEE transactions on nanobioscience · 2023Article
- Future opportunities for research in rescue treatments.Epilepsia · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus. Rescue therapies are key components of treatment plans for patients with seizure clusters. Three rescue therapies are approved in the United States for the treatment of seizure clusters: diazepam rectal gel, midazolam nasal spray, and diazepam nasal spray. This review characterizes the pharmacological function of rescue therapies for seizure clusters, as well as describing γ-aminobutyric acid A (GABA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.