Evidence map›Paper›PMID 35999024›Full record

ArticleThe international journal of neuropsychopharmacology2023

Anhedonia, Apathy, Pleasure, and Effort-Based Decision-Making in Adult and Adolescent Cannabis Users and Controls.

Martine Skumlien, Claire Mokrysz, Tom P Freeman, Vincent Valton, Matthew B Wall, Michael Bloomfield, Rachel Lees, Anna Borissova, Kat Petrilli, Manuela Giugliano and 5 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Consequences of adolescent drug use.Translational psychiatry · 2023
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Martine SkumlienDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3552-2653
Claire MokryszClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Tom P FreemanClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Vincent ValtonInstitute of Cognitive Neuroscience, Division of Psychology and Language Sciences, University College London, London, UK.
Matthew B WallClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Michael BloomfieldDivision of Psychiatry, University College London, London, UK.
Rachel LeesClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Anna BorissovaClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Kat PetrilliClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Manuela GiuglianoClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Denisa ClisuClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Christelle LangleyDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5061-2820
Barbara J SahakianDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
H Valerie CurranClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
Will LawnClinical Psychopharmacology Unit, Clinical Educational and Health Psychology Department, University College London, London, UK.
University College London · GBUniversity of Cambridge · GBKing's College London · GBInvicro (United Kingdom) · GB

Funding

Department of HealthMedical Research Council MR/P012728/1Wellcome TrustWellcome Trust 200181/Z//15/Z
6 · The paper itself

Abstract

backgroundCannabis use may be linked with anhedonia and apathy. However, previous studies have shown mixed results, and few have examined the association between cannabis use and specific reward sub-processes. Adolescents may be more vulnerable than adults to harmful effects of cannabis. This study investigated (1) the association between non-acute cannabis use and apathy, anhedonia, pleasure, and effort-based decision-making for reward; and (2) whether these relationships were moderated by age group.

methodsWe used data from the "CannTeen" study. Participants were 274 adult (26-29 years) and adolescent (16-17 years) cannabis users (1-7 d/wk use in the past 3 months) and gender- and age-matched controls. Anhedonia was measured with the Snaith-Hamilton Pleasure Scale (n = 274), and apathy was measured with the Apathy Evaluation Scale (n = 215). Effort-based decision-making for reward was measured with the Physical Effort task (n = 139), and subjective wanting and liking of rewards was measured with the novel Real Reward Pleasure task (n = 137).

resultsControls had higher levels of anhedonia than cannabis users (F1,258 = 5.35, P = .02, η p2 = .02). There were no other significant effects of user-group and no significant user-group*age-group interactions. Null findings were supported by post hoc Bayesian analyses.

conclusionOur results suggest that cannabis use at a frequency of 3 to 4 d/wk is not associated with apathy, effort-based decision-making for reward, reward wanting, or reward liking in adults or adolescents. Cannabis users had lower anhedonia than controls, albeit at a small effect size. These findings are not consistent with the hypothesis that non-acute cannabis use is associated with amotivation.

Indexed as

ApathyCannabisHallucinogensAdolescentAdultAnhedoniaBayes TheoremCannabinoid Receptor AgonistsDecision MakingHumansMotivationPleasureRewardCannabinoid Receptor AgonistsHallucinogensadolescentCannabiseffortmotivationreward

Identifiers

PMID35999024
PMCPMC9850660
OpenAlexW4293027866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.