Evidence map›Paper›PMID 35998955›Full record

ArticleBMJ open2022

Sixteen-week multicentre randomised controlled trial to study the effect of the consumption of an oat beta-glucan-enriched bread versus a whole-grain wheat bread on glycaemic control among persons with pre-diabetes: a study protocol of the CarbHealth study.

Therese Hjorth, Alena Schadow, Ingrid Revheim, Ulrike Spielau, Lise M Thomassen, Klara Meyer, Katja Piotrowski, Hanne Rosendahl-Riise, Anne Rieder, Paula Varela and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04994327 (Bread Replacement - Facing the Challenge to Improve Its Quality for Better Metabolic Health), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04994327 nacompletednot on this map

Bread Replacement - Facing the Challenge to Improve Its Quality for Better Metabolic Health

TypeinterventionalSponsorUniversity of BergenRan2021 to 2023Enrolled155ConditionsBread, Hyperglycemia, Glycemic Control, PreDiabetesArmsBeta-glucan bread
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Frontiers in nutrition · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Therese HjorthDepartment of Biology and Biological Engineering, Chalmers University of Technology, Goteborg, Sweden therese.hjorth@chalmers.se.ORCID 0000-0001-6868-833X
Alena SchadowDepartment of Exercise and Health, Paderborn University, Paderborn, Germany.
Ingrid RevheimDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Ulrike SpielauDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Lise M ThomassenDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Klara MeyerDepartment of Women and Child Health, Centre of Paediatric Research (CPL), Leipzig University, Medical Faculty, Hospital for Children and Adolescents, Leipzig, Germany.
Katja PiotrowskiDepartment of Women and Child Health, Centre of Paediatric Research (CPL), Leipzig University, Medical Faculty, Hospital for Children and Adolescents, Leipzig, Germany.
Hanne Rosendahl-RiiseDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Anne RiederNorwegian Institute of Food Fisheries and Aquaculture Research, Ås, Norway.
Paula VarelaNorwegian Institute of Food Fisheries and Aquaculture Research, Ås, Norway.
Vegard LysneDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Simon BallanceNorwegian Institute of Food Fisheries and Aquaculture Research, Ås, Norway.
Antje KoernerDepartment of Women and Child Health, Centre of Paediatric Research (CPL), Leipzig University, Medical Faculty, Hospital for Children and Adolescents, Leipzig, Germany.
Rikard LandbergDepartment of Biology and Biological Engineering, Chalmers University of Technology, Goteborg, Sweden.
Anette BuykenDepartment of Exercise and Health, Paderborn University, Paderborn, Germany.
Jutta DierkesDepartment of Exercise and Health, Paderborn University, Paderborn, Germany.ORCID 0000-0003-0663-877X
University of Bergen · NOLeipzig University · DENofima · NOPaderborn University · DEChalmers University of Technology · SEHaukeland University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn 2012, the estimated global prevalence of pre-diabetes was 280 million, and the prevalence is expected to rise to 400 million by 2030. Oat-based foods are a good source of beta-glucans, which have been shown to lower postprandial blood glucose. Studies to evaluate the effectiveness of the long-term intake of beta-glucan-enriched bread as part of a habitual diet among individuals with pre-diabetes are needed. Therefore, we designed a multicentre intervention study in adults with pre-diabetes to investigate the effects of consumption of an oat-derived beta-glucan-enriched bread as part of a normal diet on glycated haemoglobin (HbA1c) in comparison to consumption of whole-grain wheat bread. METHODS AND ANALYSIS: The CarbHealth trial is a multicentre double-blind randomised controlled 16-week dietary intervention trial in participants 40-70 years of age with a body mass index of ≥27 kg/m ETHICS AND DISSEMINATION: The study protocol was approved by respective ethical authorities in participating countries. The results of the study will be communicated through publication in international scientific journals and presentations at (inter)national conferences. TRIAL REGISTRATION NUMBER: NCT04994327.

Indexed as

beta-GlucansPrediabetic StateAdultBlood GlucoseBreadGlycated HemoglobinGlycemic ControlHumansMulticenter Studies as TopicRandomized Controlled Trials as TopicTriticumbeta-glucan, (1-3)(1-4)-beta-GlucansBlood GlucoseGlycated HemoglobinClinical trialsGeneral diabetesPUBLIC HEALTH

Identifiers

PMID35998955
PMCPMC9403155
OpenAlexW4292774319

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.