Evidence map›Paper›PMID 35998740›Full record

ArticleJournal of the American Chemical Society2022

Dual Hydrazine-Equipped Turn-On Manganese-Based Probes for Magnetic Resonance Imaging of Liver Fibrogenesis.

Yingying Ning, Iris Yuwen Zhou, Nicholas J Rotile, Pamela Pantazopoulos, Huan Wang, Stephen Cole Barrett, Mozhdeh Sojoodi, Kenneth K Tanabe, Peter Caravan

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  5. Article
  6. Selective Iridium-Catalyzed Reductive Amination Inside Living Cells.Journal of the American Chemical Society · 2025
    Article
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  14. ATP-responsive Mn(II)-basedChemical communications (Cambridge, England) · 2023
    Article
  15. Mn-Based MRI Contrast Agents: An Overview.Molecules (Basel, Switzerland) · 2023
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yingying NingAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States.ORCID 0000-0002-2942-2202
Iris Yuwen ZhouAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States.ORCID 0000-0002-4351-7398
Nicholas J RotileAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States.
Pamela PantazopoulosAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States.
Huan WangAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States.
Stephen Cole BarrettDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.ORCID 0000-0002-8764-2027
Mozhdeh SojoodiDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Kenneth K TanabeDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.
Peter CaravanAthinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States.ORCID 0000-0002-3179-6537
Massachusetts General Hospital · USHarvard University · US

Funding

Molecular MR Imaging of Hepatic FibrogenesisR01DK121789 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Peter D Caravan · 2019 to 2026
$5.0M
Carbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9M
Quantitative MRI-PET Imaging of Pulmonary FibrosisK25HL148837 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, IRIS YUWEN · 2020 to 2023
$686k
MRI-Compatible PET Insert for Small Bore ScannerS10OD023503 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2017 to 2017
$600k
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
HPLC-ICP-MS SystemS10OD010650 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2013 to 2013
$371k
Automation Equipment for Human PET Radiotracer ProductionS10OD028499 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2021 to 2021
$325k
NHLBI NIH HHS K25 HL148837NIDDK NIH HHS R01 DK121789NIH HHS S10 OD010650NIH HHS S10 OD021768NIH HHS S10 OD023503NIH HHS S10 OD025234NIH HHS S10 OD028499
6 · The paper itself

Abstract

Liver fibrogenesis is accompanied by upregulation of lysyl oxidase enzymes, which catalyze oxidation of lysine ε-amino groups on the extracellular matrix proteins to form the aldehyde containing amino acid allysine (Lys

Indexed as

Contrast MediaManganeseAnimalsHydrazinesLiverMagnetic Resonance ImagingMiceContrast MediaHydrazinesManganese

Identifiers

PMID35998740
PMCPMC10083724
OpenAlexW4293169248

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.