Evidence map›Paper›PMID 35998606›Full record

ArticleACS synthetic biology2022

Optogenetic Control of Bacterial Expression by Red Light.

Elina Multamäki, Andrés García de Fuentes, Oleksii Sieryi, Alexander Bykov, Uwe Gerken, Américo Tavares Ranzani, Jürgen Köhler, Igor Meglinski, Andreas Möglich, Heikki Takala

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
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  7. Strategies for Coexpression of Bilin-Producing Enzymes in Escherichia coli.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
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  13. Circular dichroism spectroscopy reveals multiple phytochrome photoproducts in equilibrium.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Synthetic microbiology in sustainability applications.Nature reviews. Microbiology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Elina MultamäkiDepartment of Anatomy, University of Helsinki, Helsinki 00014, Finland.
Andrés García de FuentesLehrstuhl für Biochemie, Photobiochemie, Universität Bayreuth, Bayreuth 95447, Germany.
Oleksii SieryiOptoelectronics and Measurement Techniques, University of Oulu, Oulu 90014, Finland.
Alexander BykovOptoelectronics and Measurement Techniques, University of Oulu, Oulu 90014, Finland.
Uwe GerkenLehrstuhl für Spektroskopie weicher Materie, Universität Bayreuth, Bayreuth 95447, Germany.ORCID 0000-0002-6447-2803
Américo Tavares RanzaniLehrstuhl für Biochemie, Photobiochemie, Universität Bayreuth, Bayreuth 95447, Germany.
Jürgen KöhlerLehrstuhl für Spektroskopie weicher Materie, Universität Bayreuth, Bayreuth 95447, Germany.ORCID 0000-0002-4214-4008
Igor MeglinskiOptoelectronics and Measurement Techniques, University of Oulu, Oulu 90014, Finland.
Andreas MöglichLehrstuhl für Biochemie, Photobiochemie, Universität Bayreuth, Bayreuth 95447, Germany.ORCID 0000-0002-7382-2772
Heikki TakalaDepartment of Anatomy, University of Helsinki, Helsinki 00014, Finland.ORCID 0000-0003-2518-8583
University of Bayreuth · DEUniversity of Helsinki · FIUniversity of Oulu · FIAston University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In optogenetics, as in nature, sensory photoreceptors serve to control cellular processes by light. Bacteriophytochrome (BphP) photoreceptors sense red and far-red light via a biliverdin chromophore and, in response, cycle between the spectroscopically, structurally, and functionally distinct Pr and Pfr states. BphPs commonly belong to two-component systems that control the phosphorylation of cognate response regulators and downstream gene expression through histidine kinase modules. We recently demonstrated that the paradigm BphP from

Indexed as

PhytochromeBacteriaBiliverdineHistidine KinaseLightOptogeneticsPhosphoric Monoester HydrolasesBiliverdineHistidine KinasePhosphoric Monoester HydrolasesPhytochromegene expressionoptogeneticsphytochromesensory photoreceptorsignal transductiontwo-component system

Identifiers

PMID35998606
PMCPMC9594775
OpenAlexW4292809034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.