Evidence map›Paper›PMID 35998581›Full record

ArticleDevelopmental cell2022

Rewiring bugs: Diet, the gut microbiome, and nerve regeneration.

Sarah-Jane Leigh, Gerard Clarke, John F Cryan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Antioxidants (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sarah-Jane LeighAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Gerard ClarkeAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic address: j.cryan@ucc.ie.
APC Microbiome Institute · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiome-to-nervous-system interactions are gaining much attention in fields that study health and disease, and diet is considered to be a key mediator in this communication. In a recent issue of Nature, Serger et al. show that, following nerve crush injury, intermittent fasting improves axonal regeneration through increased production of the microbially derived metabolite indole-3-propionate.

Indexed as

Gastrointestinal MicrobiomeDietNerve CrushNerve Regeneration

Identifiers

PMID35998581
OpenAlexW4292633997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.