Evidence map›Paper›PMID 35998553›Full record

ArticleDiagnostic microbiology and infectious disease2022

Evaluation of the Boson rapid Ag test vs RT-PCR for use as a self-testing platform.

Michail Leventopoulos, Vassiliki Michou, Miltiadis Papadimitropoulos, Evangelia Vourva, Nikolaos George Manias, Harilaos Panagiotis Kavvadas, Dimitris Nikolopoulos, Vassilis Tsilivakos, Georgios Georgoulias

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michail LeventopoulosDepartment of Cellular Biology and Immunology, Locus Medicus S.A., Athens, Greece. Electronic address: m_leventopoulos@yahoo.com.
Vassiliki MichouDepartment of Molecular Pathology and Genetics, Locus Medicus S.A., Athens, Greece.
Miltiadis PapadimitropoulosDepartment of Molecular Pathology and Genetics, Locus Medicus S.A., Athens, Greece.
Evangelia VourvaDepartment of Molecular Pathology and Genetics, Locus Medicus S.A., Athens, Greece.
Nikolaos George ManiasDepartment of Statistics, Locus Medicus S.A., Athens, Greece.
Harilaos Panagiotis KavvadasDepartment of Cellular Biology and Immunology, Locus Medicus S.A., Athens, Greece.
Dimitris NikolopoulosDepartment of Cellular Biology and Immunology, Locus Medicus S.A., Athens, Greece.
Vassilis TsilivakosDepartment of Cellular Biology and Immunology, Locus Medicus S.A., Athens, Greece.
Georgios GeorgouliasDepartment of Biopathology, Locus Medicus S.A., Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gold standard test available for detecting COVID-19 patients is Real Time RT-PCR. However, this method is expensive, needing special equipment and skilled laboratory staff. Recently, less expensive antigen tests have become available, that could easily and rapidly identify new COVID-19 cases. Our objective was to evaluate the Boson Rapid Antigen Test Card versus the RT-rtPCR, using samples taken both by laymen (self-testing) and professionals. The sensitivity, specificity and accuracy rates were, 98.18%, 100.00%, and 99.28%, respectively. The positive and negative predictive values were 100.00% and 98.82%, respectively. The detection rate for asymptomatic patients was 90.48%, and detection rate for Ct values ≥30 was 91.67%. Our results indicate a high coincidence rate between the Boson and the referencing RT-rtPCR method, meeting the performance standards recommended by the WHO. Therefore, this test could facilitate a fast self-testing screening method, for the detection of infected individuals.

Indexed as

COVID-19Antigens, ViralCOVID-19 TestingHumansReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Self-TestingSensitivity and SpecificityAntigens, ViralBOSONCOVID–19Rapid antigen testReal Time RT–PCRSARS–CoV–2Self–testing

Identifiers

PMID35998553
PMCPMC9335347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.