ArticleChembiochem : a European journal of chemical biology2022
Extending the Structure-Activity Relationship of Disorazole C
Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Anticancer Compounds from Myxobacteria: Current Scenario and Future Perspectives.Anti-cancer agents in medicinal chemistry · 2026Review
- Total Synthesis of (+)-Disorazole Z1.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Synthesis of a Non-Symmetrical Disorazole CMolecules (Basel, Switzerland) · 2024Article
- Yamaguchi esterification: a key step toward the synthesis of natural products and their analogs-a review.Frontiers in chemistry · 2024Review
- Extending the Structure-Activity Relationship of Disorazole CChembiochem : a European journal of chemical biology · 2022Article
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Authors and funding
5 authors.
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Abstract
The synthesis of novel disorazole C1 analogues is described and their biological activity as cytotoxic compounds is reported. Based on our convergent entry to the disorazole core we present a flexible and robust strategy to construct a variety of interesting new analogues. In particular, two regions of the molecules were examined for structural modification: 1. Replacement of the heterocyclic moiety by an exchange of the oxazole ring by a thiazole; and 2. Evaluation of the influence of the absolute configuration of the chiral centers of the molecule. Predicated on our flexible strategy we were able to construct all analogues in an efficient way and could perform an exciting SAR (structure-activity-relationship) study to obtain insight in the cytotoxic activity influenced by the chiral centers of the disorazole core.
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