ArticleClinical and translational medicine2022
Healthy and unhealthy plant-based diets in relation to the incidence of colorectal cancer overall and by molecular subtypes.
Article in Clinical and translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dietary patterns and colorectal cancer risk: Global Cancer Update Programme (CUP Global) systematic literature review.The American journal of clinical nutrition · 2025Pooled it
- DASH, Mediterranean, and Plant-Based Diets and Cancer Risk in Women: A Narrative Review Based on Diet Quality Indices.Nutrients · 2026Review
- Article
- Plant-based diet quality is associated with esophageal mucosa-associated microbiome profiles and disease severity in a high-risk Chinese population.Journal of oral microbiology · 2026Article
- Diets for Dual Cardiovascular and Planetary Health: A Scoping Review.Current atherosclerosis reports · 2025Article
- The 3V score and joint associations of low ultra-processed food, biodiverse and plant-based diets on colorectal cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study.EClinicalMedicine · 2025Article
- Not All Plants Are Equal: Diet Quality and Inflammation in Vegans and Vegetarians in Urban Poland.Nutrients · 2025Article
- Association of dietary total antioxidant capacity with KRAS gene mutation in metastatic colorectal cancer patients: a case-control study.Genes & nutrition · 2025Article
- Measuring and Forecasting the Healthy Eating Index in Iran: 1991-2027.International journal of preventive medicine · 2025Article
- Relationship Between Dietary Acid Load and Risk of Metastatic Colorectal Cancer: A Case-Control Study.Current therapeutic research, clinical and experimental · 2025Article
- Slower Pace of Epigenetic Aging and Lower Inflammatory Indicators in Females Following a Nutrient-Dense, Plant-Rich Diet Than Those in Females Following the Standard American Diet.Current developments in nutrition · 2024Article
- A healthful plant-based diet can reduce the risk of developing colorectal cancer: case-control study.Journal of health, population, and nutrition · 2024Article
- The Crucial Roles of Diet, Microbiota, and Postbiotics in Colorectal Cancer.Current nutrition reports · 2024Review
- Plant-based diets and the gut microbiome: findings from the Baltimore Longitudinal Study of Aging.The American journal of clinical nutrition · 2024Article
- Causal associations between dietary factors and colorectal cancer risk: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- The association between pro-vegetarian dietary pattern and risk of colorectal cancer: a matched case-control study.BMC research notes · 2023Article
- Plant-based dietary patterns, genetic predisposition and risk of colorectal cancer: a prospective study from the UK Biobank.Journal of translational medicine · 2023Article
- Vegetarian and vegan diets: benefits and drawbacks.European heart journal · 2023Article
- Heterogeneity of the tumor immune microenvironment and clinical interventions.Frontiers of medicine · 2023Review
- Yacon (Nutrients · 2023Article
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21 authors.
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Abstract
backgroundPlant-based foods have been recommended for health. However, not all plant foods are healthy, and little is known about the association between plant-based diets and specific molecular subtypes of colorectal cancer (CRC). We examined the associations of healthy and unhealthy plant-based diets with the incidence of CRC and its molecular subtypes.
methodsWhile 123 773 participants of the Nurses' Health Study and the Health Professionals Follow-up Study had been followed up (3 143 158 person-years), 3077 of them had developed CRC. Healthy and unhealthy plant-based diet indices (hPDI and uPDI, respectively) were calculated using repeated food frequency questionnaire data. We determined the tumoural status of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and BRAF and KRAS mutations.
resultsHigher hPDI was associated with lower CRC incidence (multivariable hazard ratio [HR] comparing extreme quartiles, 0.86, 95% confidence interval [CI]: 0.77, 0.96; P-trend = .04), whereas higher uPDI was associated with higher CRC incidence (multivariable HR comparing extreme quartiles, 1.16, 95% CI: 1.04, 1.29; P-trend = .005). The association of hPDI significantly differed by KRAS status (P-heterogeneity = .003) but not by other tumour markers. The hPDI was associated with lower incidence of KRAS-wildtype CRC (multivariable HR comparing extreme quartiles, 0.74, 95% CI: 0.57, 0.96; P-trend = .004) but not KRAS-mutant CRC (P-trend = .22).
conclusionsWhile unhealthy plant-based diet enriched with refined grains and sugar is associated with higher CRC incidence, healthy plant-based diet rich in whole grains, fruits and vegetables is associated with lower incidence of CRC, especially KRAS-wildtype CRC.
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