Evidence map›Paper›PMID 35997792›Full record

ReviewIntensive care medicine2022

Electroencephalogram in the intensive care unit: a focused look at acute brain injury.

Ayham Alkhachroum, Brian Appavu, Satoshi Egawa, Brandon Foreman, Nicolas Gaspard, Emily J Gilmore, Lawrence J Hirsch, Pedro Kurtz, Virginie Lambrecq, Julie Kromm and 4 more

Abstract readReview
In one paragraph

Review in Intensive care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Addressing challenges for virtual reality applications in the ICU.Journal of anesthesia, analgesia and critical care · 2026
    Article
  4. Article
  5. Article
  6. Covert brain complexity in the intensive care unit.Cortex; a journal devoted to the study of the nervous system and behavior · 2026
    Article
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  10. Observational
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ayham Alkhachroum *Department of Neurology, University of Miami, Miami, FL, USA.
Brian Appavu *Department of Child Health and Neurology, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
Satoshi EgawaNeurointensive Care Unit, Department of Neurosurgery, and Stroke and Epilepsy Center, TMG Asaka Medical Center, Saitama, Japan.
Brandon ForemanDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH, USA.
Nicolas GaspardDepartment of Neurology, Erasme Hospital, Free University of Brussels, Brussels, Belgium.
Emily J GilmoreComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Lawrence J HirschComprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Pedro KurtzDepartment of Intensive Care Medicine, D'or Institute for Research and Education, Rio de Janeiro, Brazil.
Virginie LambrecqDepartment of Clinical Neurophysiology and Epilepsy Unit, AP-HP, Pitié Salpêtrière Hospital, Reference Center for Rare Epilepsies, 75013, Paris, France.
Julie KrommDepartments of Critical Care Medicine and Clinical Neurosciences, Cumming School of Medicine, Calgary, AB, Canada.
Paul VespaBrain Injury Research Center, Department of Neurosurgery, University of California, Los Angeles, USA.
Sahar F ZafarDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Benjamin Rohaut *Department of Neurology, Sorbonne Université, Pitié-Salpêtrière-AP-HP and Paris Brain Institute, ICM, Inserm, CNRS, Paris, France.
Jan Claassen *Department of Neurology, Neurological Institute, Columbia University, New York Presbyterian Hospital, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York, NY, 10032, USA. jc1439@columbia.edu.ORCID http://orcid.org/0000-0002-5893-8531

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGeR01NS106014 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2023
$3.6M
ELECTRO-BOOST: Electroencephalography for cerebral trauma recovery and oxygenationR01NS117904 · NINDS · YALE UNIVERSITY · PI DING, KAN, GILMORE, EMILY · 2020 to 2025
$3.2M
Optimizing anti-epileptic drug treatment in acute brain injuryK23NS114201 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ZAFAR, SAHAR F · 2019 to 2023
$1.0M
MUSICA - MUsic and Speech Induced Cerebral ActivationK23NS126577 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Ayham Alkhachroum · 2022 to 2026
$910k
BAsIC - Brain-computer-interface practical Application in the Intensive Care unit: a pilot studyR03NS112760 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2020
$162k
NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002736NINDS NIH HHS K23 NS114201NINDS NIH HHS K23 NS126577NINDS NIH HHS R01 NS106014NINDS NIH HHS R01 NS117904NINDS NIH HHS R03 NS112760
6 · The paper itself

Abstract

Over the past decades, electroencephalography (EEG) has become a widely applied and highly sophisticated brain monitoring tool in a variety of intensive care unit (ICU) settings. The most common indication for EEG monitoring currently is the management of refractory status epilepticus. In addition, a number of studies have associated frequent seizures, including nonconvulsive status epilepticus (NCSE), with worsening secondary brain injury and with worse outcomes. With the widespread utilization of EEG (spot and continuous EEG), rhythmic and periodic patterns that do not fulfill strict seizure criteria have been identified, epidemiologically quantified, and linked to pathophysiological events across a wide spectrum of critical and acute illnesses, including acute brain injury. Increasingly, EEG is not just qualitatively described, but also quantitatively analyzed together with other modalities to generate innovative measurements with possible clinical relevance. In this review, we discuss the current knowledge and emerging applications of EEG in the ICU, including seizure detection, ischemia monitoring, detection of cortical spreading depolarizations, assessment of consciousness and prognostication. We also review some technical aspects and challenges of using EEG in the ICU including the logistics of setting up ICU EEG monitoring in resource-limited settings.

Indexed as

Brain InjuriesStatus EpilepticusElectroencephalographyHumansIntensive Care UnitsSeizuresCortical spreading depolarizationDisorders of consciousnessElectroencephalogramIntensive care unitIschemiaNonconvulsive seizuresStatus epilepticus

Identifiers

PMID35997792
PMCPMC10008537

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.