Evidence map›Paper›PMID 35997524›Full record

ArticleCancer science2022

Impact of intratumoural CD96 expression on clinical outcome and therapeutic benefit in gastric cancer.

Chang Xu, Hanji Fang, Yun Gu, Kuan Yu, Jieti Wang, Chao Lin, Heng Zhang, He Li, Hongyong He, Hao Liu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CD8 + T Cells in Gastrointestinal Cancer: a Perspective on Targeting MicroRNA.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chang XuDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hanji FangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yun GuDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Kuan YuDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Jieti WangDepartment of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Chao LinDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Heng ZhangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
He LiDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hongyong HeDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hao LiuDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Ruochen LiDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-4013-3281
Sun Yat-sen University · CNFudan University Shanghai Cancer Center · CN

Funding

National Natural Science Foundation of China 81871930National Natural Science Foundation of China 81902402National Natural Science Foundation of China 81902901National Natural Science Foundation of China 81972219National Natural Science Foundation of China 82003019National Natural Science Foundation of China 82103313Shanghai Rising-Star Program 22QA1401700Shanghai Sailing Program 18YF1404600Shanghai Sailing Program 19YF1407500Shanghai Sailing Program 21YF1407600
6 · The paper itself

Abstract

CD96 was identified as a novel immune checkpoint. However, the role of CD96 in the gastric cancer (GC) microenvironment remains fragmentary. This study aimed to probe the clinical significance of CD96 to predict prognosis and therapeutic responsiveness, and to reveal the immune contexture and genomic features correlated to CD96 in GC patients. We enrolled 496 tumor microarray specimens of GC patients from Zhongshan Hospital (ZSHS) for immunohistochemical analyses. Four hundred and twelve GC patients from the Cancer Genome Atlas (TCGA) and 61 GC patients treated with pembrolizumab from ERP107734 published in the European Nucleotide Archive (ENA) were gathered for further analysis of the association between CD96

Indexed as

Stomach NeoplasmsChemotherapy, AdjuvantFluorouracilHumansImmunotherapyPrognosisTumor MicroenvironmentFluorouracilCD96gastric cancerprognosistherapeutic responsetumor microenvironment

Identifiers

PMID35997524
PMCPMC9746045
OpenAlexW4292722544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.