Evidence map›Paper›PMID 35997362›Full record

ReviewNeurology international2022

Novel Designer Benzodiazepines: Comprehensive Review of Evolving Clinical and Adverse Effects.

Amber N Edinoff, Catherine A Nix, Amira S Odisho, Caroline P Babin, Alyssa G Derouen, Salim C Lutfallah, Elyse M Cornett, Kevin S Murnane, Adam M Kaye, Alan D Kaye

Open access · goldAbstract readReview
In one paragraph

Review in Neurology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Eco-Friendly Access to Indenodiazepinones fromACS medicinal chemistry letters · 2026
    Article
  3. Review
  4. Article
  5. In vitro γ-aminobutyric acid A (GABACommunications chemistry · 2026
    Article
  6. Synergistic Effect ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  11. New psychoactive substances: a multidisciplinary review of challenges and their diverse character.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Frontiers in psychiatry · 2024
    Article
  18. Add-On Treatment withPharmaceuticals (Basel, Switzerland) · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Amber N EdinoffDepartment of Psychiatry, Massachusetts General Hospital, Harvard School of Medicine, Boston, MA 02114, USA.ORCID 0000-0001-7436-6206
Catherine A NixDepartment of Psychiatry and Behavioral Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
Amira S OdishoDepartment of Psychiatry and Behavioral Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
Caroline P BabinSchool of Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
Alyssa G DerouenSchool of Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
Salim C LutfallahSchool of Medicine, Louisiana State University New Orleans, New Orleans, LA 70112, USA.
Elyse M CornettDepartment of Anesthesiology, Louisiana State University Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0001-7961-3931
Kevin S MurnaneDepartment of Psychiatry, Massachusetts General Hospital, Harvard School of Medicine, Boston, MA 02114, USA.
Adam M KayeThomas J. Long School of Pharmacy and Health Sciences, Department of Pharmacy Practice, University of the Pacific, Stockton, CA 95211, USA.ORCID 0000-0002-7224-3322
Alan D KayeDepartment of Psychiatry and Behavioral Medicine, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
Louisiana State University in Shreveport · USLouisiana State University · USUniversity of the Pacific · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As tranquilizers, benzodiazepines have a wide range of clinical uses. Recently, there has been a significant rise in the number of novel psychoactive substances, including designer benzodiazepines. Flubromazolam(8-bromo-6-(2-fluorophenyl)-1-methyl-4

Indexed as

adverse effectsbenzodiazepinesdeschloroetizolamdesigner drugsflubromazolam(8-bromo-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine) clonazolammeclonazepamwithdrawal

Identifiers

PMID35997362
PMCPMC9397074
OpenAlexW4292687860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.