Evidence map›Paper›PMID 35997304›Full record

ArticleHypertension in pregnancy

Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease?

Fernando Sontag, Sonja Suvakov, Vesna D Garovic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension in pregnancy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Fernando SontagDivision of Nephrology & Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Sonja SuvakovDivision of Nephrology & Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Vesna D GarovicDivision of Nephrology & Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USUniversidade Federal de São Paulo · BR

Funding

Hypertensive pregnancy disorders and future coronary artery diseaseR01HL136348 · NHLBI · MAYO CLINIC ROCHESTER · PI GAROVIC, VESNA D · 2018 to 2022
$2.6M
NHLBI NIH HHS R01 HL136348
6 · The paper itself

Abstract

objectiveThe aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy.

methodsUrine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH).

resultsSomatic ACE protein expression was higher in PE+SPE compared to N and GH. There was a positive correlation between ACE and urinary protein to creatinine ratio, systolic and diastolic blood pressures.

conclusionThese results indicate ACE overexpression in the urine of preeclamptic patients and suggest that it may be a new marker for the disease.

Indexed as

HypertensionPre-EclampsiaBlood PressureFemaleHumansPeptidyl-Dipeptidase APregnancyRenin-Angiotensin SystemPeptidyl-Dipeptidase Aangiotensin converting enzymehypertensive pregnancy disorderPreeclampsiarenin angiotensin aldosterone system

Identifiers

PMID35997304
PMCPMC9771896
OpenAlexW4292731142

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.