Evidence map›Paper›PMID 35997258›Full record

ArticleeLife2022

Species-specific chromatin landscape determines how transposable elements shape genome evolution.

Yuheng Huang, Harsh Shukla, Yuh Chwen G Lee

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Machine learning reveals sequence and genomic context features underlyingbioRxiv : the preprint server for biology · 2026
    Article
  2. Nuclear genome profiling of two species ofNAR genomics and bioinformatics · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Polymorphic 3D genome architecture mediated by transposable elements.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Polymorphic transposable elements contribute to variation in recombination landscapes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuheng HuangDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, United States.ORCID 0000-0002-1586-953X
Harsh ShuklaDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, United States.
Yuh Chwen G LeeDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, United States.ORCID 0000-0002-0081-7892

Funding

How transposable elements drive genome evolution through epigenetic mechanismsR35GM142494 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Grace Yuh Chwen Lee · 2021 to 2026
$2.5M
Bioelectrochemistry at the Nanoscale: Fundamentals and ApplicationsR35GM142920 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SEPUNARU, LIOR · 2021 to 2025
$1.7M
Functional and evolutionary consequences of the epigenetic effects of transposable elementsR00GM121868 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LEE, GRACE YUH CHWEN · 2019 to 2020
$498k
NIGMS NIH HHS R00 GM121868NIGMS NIH HHS R35 GM142494NIGMS NIH HHS R35 GM142920
6 · The paper itself

Abstract

Transposable elements (TEs) are selfish genetic parasites that increase their copy number at the expense of host fitness. The 'success', or genome-wide abundance, of TEs differs widely between species. Deciphering the causes for this large variety in TE abundance has remained a central question in evolutionary genomics. We previously proposed that species-specific TE abundance could be driven by the inadvertent consequences of host-direct epigenetic silencing of TEs-the spreading of repressive epigenetic marks from silenced TEs into adjacent sequences. Here, we compared this TE-mediated local enrichment of repressive marks, or 'the epigenetic effect of TEs', in six species in the

Indexed as

DNA Transposable ElementsDrosophila melanogasterAnimalsChromatinDrosophilaEvolution, MolecularPhylogenyChromatinDNA Transposable ElementschromatinD. melanogasterepigeneticsevolutionary biologygenome evolutionheterochromatinpopulation geneticstransposable element

Identifiers

PMID35997258
PMCPMC9398452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.