ArticlePhotochemistry and photobiology2023
Evaluation of Detector Position and Light Fluence Distribution Using an Infrared Navigation System during Pleural Photodynamic Therapy
Article in Photochemistry and photobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.Journal of biomedical optics · 2024Article
- PDT Light Fluence Phantom Modeling of the Human Pleural Cavity: A Proof-of-Concept Pre-Clinical Study.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- A real-time IR navigation system for pleural photodynamic therapy with a 3D surface acquisition system.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- Comprehensive reanalysis of light fluence distribution in pleural photodynamic therapy using standardized anatomical coordinates.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Photodynamic therapy (PDT) has been used to treat malignant pleural mesothelioma. Current practice involves delivering light to a prescribed light fluence with a point source, monitored by eight isotropic detectors inside the pleural cavity. An infrared (IR) navigation system was used to track the location of the point source throughout the treatment. The recorded data were used to reconstruct the pleural cavity and calculate the light fluence to the whole cavity. An automatic algorithm was developed recently to calculate the detector positions based on recorded data within an hour. This algorithm was applied to patient case studies and the calculated results were compared to the measured positions, with an average difference of 2.5 cm. Calculated light fluence at calculated positions were compared to measured values. The differences between the calculated and measured light fluence were within 14% for all cases, with a fixed scattering constant and a dual correction method. Fluence-surface histogram (FSH) was calculated for photofrin-mediated PDT to be able to cover 80% of pleural surface area to 50 J cm
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Registered trials
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