ArticleCNS neuroscience & therapeutics2022
Specific subsystems of the inferior parietal lobule are associated with hand dysfunction following stroke: A cross-sectional resting-state fMRI study.
Article in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Research trends and hotspots of post-stroke upper limb dysfunction: a bibliometric and visualization analysis.Frontiers in neurology · 2024Pooled it
- Motor network reorganization after motor imagery training in stroke patients with moderate to severe upper limb impairment.CNS neuroscience & therapeutics · 2023Trial
- Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation.BMC medicine · 2026Article
- Neuroimaging and biological markers of different paretic hand outcomes after stroke.Journal of neuroengineering and rehabilitation · 2025Article
- Identifying biomarkers related to motor function in chronic stroke: A fNIRS and TMS study.CNS neuroscience & therapeutics · 2024Article
- Posterior parietal cortical areas and recovery after motor stroke: a scoping review.Brain communications · 2023Article
- Specific subsystems of the inferior parietal lobule are associated with hand dysfunction following stroke: A cross-sectional resting-state fMRI study.CNS neuroscience & therapeutics · 2022Article
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Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe inferior parietal lobule (IPL) plays important roles in reaching and grasping during hand movements, but how reorganizations of IPL subsystems underlie the paretic hand remains unclear. We aimed to explore whether specific IPL subsystems were disrupted and associated with hand performance after chronic stroke.
methodsIn this cross-sectional study, we recruited 65 patients who had chronic subcortical strokes and 40 healthy controls from China. Each participant underwent the Fugl-Meyer Assessment of Hand and Wrist and resting-state fMRI at baseline. We mainly explored the group differences in resting-state effective connectivity (EC) patterns for six IPL subregions in each hemisphere, and we correlated these EC patterns with paretic hand performance across the whole stroke group and stroke subgroups. Moreover, we used receiver operating characteristic curve analysis to distinguish the stroke subgroups with partially (PPH) and completely (CPH) paretic hands.
resultsStroke patients exhibited abnormal EC patterns with ipsilesional PFt and bilateral PGa, and five sensorimotor-parietal/two parietal-temporal subsystems were positively or negatively correlated with hand performance. Compared with CPH patients, PPH patients exhibited abnormal EC patterns with the contralesional PFop. The PPH patients had one motor-parietal subsystem, while the CPH patients had one sensorimotor-parietal and three parietal-occipital subsystems that were associated with hand performance. Notably, the EC strength from the contralesional PFop to the ipsilesional superior frontal gyrus could distinguish patients with PPH from patients with CPH.
conclusionsThe IPL subsystems manifest specific functional reorganization and are associated with hand dysfunction following chronic stroke.
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