ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2022
Genetic assortative mating for schizophrenia and bipolar disorder.
Article in European psychiatry : the journal of the Association of European Psychiatrists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Aberrant network topology of cortical-subcortical circuits in schizophrenia and bipolar disorder: a graph theory study.Frontiers in psychiatry · 2026Article
- Assortative Mating Across the Full Spectrum of Mental Disorders: A Nationwide Finnish Register Study.Biological psychiatry global open science · 2026Article
- Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior.The European journal of neuroscience · 2025Article
- Addressing overfitting bias due to sample overlap in polygenic risk scoring.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Non-random mating patterns within and across education and mental and somatic health.Nature communications · 2024Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- Non-random Mating Patterns in Education, Mental, and Somatic Health: A Population Study on Within- and Cross-Trait Associations.medRxiv : the preprint server for health sciences · 2024Article
- Assortative mating and parental genetic relatedness contribute to the pathogenicity of variably expressive variants.American journal of human genetics · 2023Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRSs).
methodsPRSs from The Danish High-Risk and Resilience Study-VIA 7 were compared between parents in three subsamples: population-based control parent pairs (
resultsThe PRS for schizophrenia was predictive of schizophrenia in the full sample and showed a significant correlation between parent pairs (
conclusionsOur study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.
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