Evidence map›Paper›PMID 35996866›Full record

SynthesisEpilepsia2022

Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta-analysis.

Frederick P Mariajoseph, Zhibin Chen, Praba Sekhar, Sarah S Rewell, Terence J O'Brien, Ana Antonic-Baker, Bridgette D Semple

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  15. Article
  16. Posttraumatic epilepsy in critically ill children with traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  17. An update on pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
  18. Review
  19. Pre-existingFrontiers in molecular neuroscience · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Frederick P MariajosephSchool of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
Zhibin ChenDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-1888-6917
Praba SekharSchool of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
Sarah S RewellDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Terence J O'BrienDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Ana Antonic-BakerDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Bridgette D SempleDepartment of Neuroscience, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-2535-0491
Monash University · AUThe Royal Melbourne Hospital · AUAlfred Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posttraumatic epilepsy (PTE) is a well-known chronic complication following traumatic brain injury (TBI). Despite some evidence that age at the time of injury may influence the likelihood of PTE, the incidence of PTE in pediatric populations remains unclear. We therefore conducted a systematic review to determine the overall reported incidence of PTE, and explore potential risk factors associated with PTE after pediatric TBI. A comprehensive literature search of the PubMed, Embase, and Web of Science databases was conducted, including randomized controlled trials and cohort studies assessing the incidence of PTE in TBI pediatric patients. We excluded studies with a sample size of <10 patients and those in which a pediatric cohort was not clearly discernable. The review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We found that the overall incidence of PTE following pediatric TBI was 10% (95% confidence interval [CI] = 5.9%-15%). Subgroup analysis of a small number of studies demonstrated that the occurrence of early seizures (cumulative incidence ratio [CIR] = 7.28, 95% CI = 1.09-48.4, p = .040), severe TBI (CIR = 1.81, 95% CI = 1.23-2.67, p < .001), and intracranial hemorrhage (CIR = 1.60, 95% CI = 1.06-2.40, p = .024) increased the risk of PTE in this population. Other factors, including male sex and neurosurgical intervention, were nonsignificantly associated with a higher incidence of PTE. In conclusion, PTE is a significant chronic complication following childhood TBI, similar to in the adult population. Further standardized investigation into clinical risk factors and management guidelines is warranted. PROSPERO ID# CRD42021245802.

Indexed as

Brain Injuries, TraumaticEpilepsy, Post-TraumaticAdultChildCohort StudiesHumansIncidenceMaleRisk Factorschildhoodepilepsyincidenceneurotraumapediatricposttraumatic epilepsyseizuretraumatic brain injury

Identifiers

PMID35996866
PMCPMC9826023
OpenAlexW4292714594

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.