Evidence map›Paper›PMID 35996667›Full record

ArticlePeerJ2022

Complex interactions between p.His558Arg and linked variants in the sodium voltage-gated channel alpha subunit 5 (Na

Monica Lopes-Marques, Raquel Silva, Catarina Serrano, Verónica Gomes, Ana Cardoso, Maria João Prata, Antonio Amorim, Luisa Azevedo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Monica Lopes-MarquesIPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.ORCID 0000-0002-8597-4730
Raquel SilvaCenter for Interdisciplinary Research in Health (CIIS), Universidade Católica Portuguesa, Faculdade de Medicina Dentária, Viseu, Portugal.
Catarina SerranoIPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
Verónica GomesIPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
Ana CardosoIPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
Maria João PrataIPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
Antonio AmorimIPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.ORCID 0000-0002-7518-6247
Luisa AzevedoIPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Common genetic polymorphisms may modify the phenotypic outcome when co-occurring with a disease-causing variant, and therefore understanding their modulating role in health and disease is of great importance. The polymorphic p.His558Arg variant of the sodium voltage-gated channel alpha subunit 5 (Na

Indexed as

Electrophysiological PhenomenaPolymorphism, GeneticHumansNAV1.5 Voltage-Gated Sodium ChannelPhenotypeSodiumNAV1.5 Voltage-Gated Sodium ChannelSodiumBrugada syndromeCardiac channelCardiac diseasesEpistasisGenetic backgroundGenetic modifierLinkage disequilibriumSCN5A variantsSodium voltage-gated channel alpha subunit 5 (NaV1.5)

Identifiers

PMID35996667
PMCPMC9392453

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.